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10.1038/srep37442

http://scihub22266oqcxt.onion/10.1038/srep37442
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suck abstract from ncbi


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pmid27874074
      Sci+Rep 2016 ; 6 (ä): 37442
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  • Second-trimester urine nephrin:creatinine ratio versus soluble fms-like tyrosine kinase-1:placental growth factor ratio for prediction of preeclampsia among asymptomatic women #MMPMID27874074
  • Zhai T ; Furuta I ; Nakagawa K ; Kojima T ; Umazume T ; Ishikawa S ; Yamada T ; Morikawa M ; Minakami H
  • Sci Rep 2016[Nov]; 6 (ä): 37442 PMID27874074 show ga
  • This prospective observational study compare urine nephrin:creatinine ratio (NCR, ng/mg) with serum soluble fms-like tyrosine kinase-1:placental growth factor ratio (FPR, pg/pg) for preeclampsia (PE) prediction among unselected asymptomatic pregnant women in 2(nd) trimester. NCR and FPR were determined in 254 paired urine/blood samples collected simultaneously from 254 women at median gestational week (GW) 24 (range, 22-27) without hypertension or significant proteinuria in pregnancy (SPIP). Fifteen (5.9%) developed SPIP and hypertension at GW 34.0 (26.0-38.6) and 35.3 (27.6-38.6), respectively, and were diagnosed with PE at GW 35.7 (27.6-38.6). The 90(th) percentile level determined in 239 women normotensive throughout pregnancy gave NCR (139) sensitivity and positive predictive values (PPV) of 60% (9/15) and 27% (9/33), while those for serum FPR (4.85) were 40% (6/15) and 20% (6/30), respectively. Relative risks (95%CI) of later PE were 10.0 (3.82-26.4; 27% [9/33] vs. 2.7% [6/221]) and 4.98 (1.91-13.0; 20% [6/30] vs. 4.0% [9/224]) for NCR-positive and FPR-positive women, respectively. Cut-offs suggested by ROC gave NCR (86.6) sensitivity and PPV of 87% (13/15) and 17% (13/79), and FPR (8.8) values of 40% (6/15) and 40% (6/15), respectively. Thus, 2(nd) trimester NCR was superior to FPR for PE prediction.
  • |Adult [MESH]
  • |Creatinine/*urine [MESH]
  • |Demography [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Hypertension/urine [MESH]
  • |Mass Screening [MESH]
  • |Membrane Proteins/*urine [MESH]
  • |Middle Aged [MESH]
  • |Placenta Growth Factor/*urine [MESH]
  • |Pre-Eclampsia/*diagnosis/*urine [MESH]
  • |Pregnancy [MESH]
  • |Pregnancy Trimester, Second/*urine [MESH]
  • |Proteinuria/urine [MESH]
  • |Solubility [MESH]
  • |Vascular Endothelial Growth Factor Receptor-1/*urine [MESH]


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