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2016 ; 6
(ä): 37442
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Second-trimester urine nephrin:creatinine ratio versus soluble fms-like tyrosine
kinase-1:placental growth factor ratio for prediction of preeclampsia among
asymptomatic women
#MMPMID27874074
Zhai T
; Furuta I
; Nakagawa K
; Kojima T
; Umazume T
; Ishikawa S
; Yamada T
; Morikawa M
; Minakami H
Sci Rep
2016[Nov]; 6
(ä): 37442
PMID27874074
show ga
This prospective observational study compare urine nephrin:creatinine ratio (NCR,
ng/mg) with serum soluble fms-like tyrosine kinase-1:placental growth factor
ratio (FPR, pg/pg) for preeclampsia (PE) prediction among unselected asymptomatic
pregnant women in 2(nd) trimester. NCR and FPR were determined in 254 paired
urine/blood samples collected simultaneously from 254 women at median gestational
week (GW) 24 (range, 22-27) without hypertension or significant proteinuria in
pregnancy (SPIP). Fifteen (5.9%) developed SPIP and hypertension at GW 34.0
(26.0-38.6) and 35.3 (27.6-38.6), respectively, and were diagnosed with PE at GW
35.7 (27.6-38.6). The 90(th) percentile level determined in 239 women
normotensive throughout pregnancy gave NCR (139) sensitivity and positive
predictive values (PPV) of 60% (9/15) and 27% (9/33), while those for serum FPR
(4.85) were 40% (6/15) and 20% (6/30), respectively. Relative risks (95%CI) of
later PE were 10.0 (3.82-26.4; 27% [9/33] vs. 2.7% [6/221]) and 4.98 (1.91-13.0;
20% [6/30] vs. 4.0% [9/224]) for NCR-positive and FPR-positive women,
respectively. Cut-offs suggested by ROC gave NCR (86.6) sensitivity and PPV of
87% (13/15) and 17% (13/79), and FPR (8.8) values of 40% (6/15) and 40% (6/15),
respectively. Thus, 2(nd) trimester NCR was superior to FPR for PE prediction.