Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/srep37492 http://scihub22266oqcxt.onion/10.1038/srep37492 C5118685!5118685 !27874055     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27874055 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 37492 Nephropedia Template TP {{tp|p=27874055 |t=2016. The coordinated roles of miR-26a and miR-30c in regulating TGF?1-induced epithelial-to-mesenchymal transition in diabetic nephropathy |pdf=|usr=}}{{27874055 }} gab.com Text The coordinated roles of miR-26a and miR-30c in regulating TGF 1-induced epithelial-to-mesenchymal transition in diabetic nephropathy JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27874055 #FOAvip MicroRNAs (miRNAs) play vital roles in the development of diabetic nephropathy. Here, we compared the protective efficacies of miR-26a and miR-30c in renal tubular epithelial cells (NRK-52E) and determined whether they demonstrated additive effects in the attenuation of renal fibrosis. TGF?1 suppressed miR-26a and miR-30c expression but up-regulated pro-fibrotic markers in NRK-52E cells, and these changes were also found in the kidney cortex of 40-week-old diabetic Otsuka Long-Evans Tokushima fatty (OLETF) rats. Bioinformatic analyses and luciferase assays further demonstrated that both miR-26a and miR-30c targeted connective tissue growth factor (CTGF); additionally, Snail family zinc finger 1 (Snail1), a potent epithelial-to-mesenchymal transition (EMT) inducer, was targeted by miR-30c. Overexpression of miR-26a and miR-30c coordinately decreased CTGF protein levels and subsequently ameliorated TGF?1-induced EMT in NRK-52E cells. Co-silencing of miR-26a and miR-30c exhibited the opposite effect. Moreover, miR-26a and miR-30c co-silenced CTGF to decrease ERK1/2 and p38 MAPK activation. Furthermore, miR-26a was up-regulated in urinary extracellular vesicles of diabetic nephropathy patients. Our study provides evidence for the cooperative roles of miR-26a and miR-30c in the pathogenesis of diabetic nephropathy, and the co-targeting of miR-26a and miR-30c could provide a new direction for diabetic nephropathy treatment. Twit Text FOAVip The coordinated roles of miR-26a and miR-30c in regulating TGF 1-induced epithelial-to-mesenchymal transition in diabetic nephropathy ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27874055 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27874055 #FOAvip English Wikipedia <ref>{{Cite pmid|27874055 }}</ref> The coordinated roles of miR-26a and miR-30c in regulating TGF?1-induced epithelial-to-mesenchymal transition in diabetic nephropathy #MMPMID27874055 Zheng Z ; Guan M ; Jia Y ; Wang D ; Pang R ; Lv F ; Xiao Z ; Wang L ; Zhang H ; Xue Y Sci Rep 2016[Nov]; 6 (ä): 37492 PMID27874055 show ga MicroRNAs (miRNAs) play vital roles in the development of diabetic nephropathy. Here, we compared the protective efficacies of miR-26a and miR-30c in renal tubular epithelial cells (NRK-52E) and determined whether they demonstrated additive effects in the attenuation of renal fibrosis. TGF?1 suppressed miR-26a and miR-30c expression but up-regulated pro-fibrotic markers in NRK-52E cells, and these changes were also found in the kidney cortex of 40-week-old diabetic Otsuka Long-Evans Tokushima fatty (OLETF) rats. Bioinformatic analyses and luciferase assays further demonstrated that both miR-26a and miR-30c targeted connective tissue growth factor (CTGF); additionally, Snail family zinc finger 1 (Snail1), a potent epithelial-to-mesenchymal transition (EMT) inducer, was targeted by miR-30c. Overexpression of miR-26a and miR-30c coordinately decreased CTGF protein levels and subsequently ameliorated TGF?1-induced EMT in NRK-52E cells. Co-silencing of miR-26a and miR-30c exhibited the opposite effect. Moreover, miR-26a and miR-30c co-silenced CTGF to decrease ERK1/2 and p38 MAPK activation. Furthermore, miR-26a was up-regulated in urinary extracellular vesicles of diabetic nephropathy patients. Our study provides evidence for the cooperative roles of miR-26a and miR-30c in the pathogenesis of diabetic nephropathy, and the co-targeting of miR-26a and miR-30c could provide a new direction for diabetic nephropathy treatment. |Animals [MESH] |Base Sequence [MESH] |Connective Tissue Growth Factor/metabolism [MESH] |Diabetic Nephropathies/*genetics/*pathology [MESH] |Down-Regulation/drug effects [MESH] |Epithelial-Mesenchymal Transition/*drug effects/genetics [MESH] |Extracellular Vesicles/drug effects/metabolism [MESH] |Fibrosis [MESH] |Humans [MESH] |MicroRNAs/*metabolism [MESH] |Models, Biological [MESH] |Rats [MESH] |Rats, Inbred OLETF [MESH] |Signal Transduction/drug effects [MESH] |Snail Family Transcription Factors/metabolism [MESH] |Transforming Growth Factor beta1/*pharmacology [MESH]The coordinated roles of miR-26a and miR-30c in regulating TGF?1-induc(epmc).pdf DeepDyve Pubget Overpricing