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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Cancer
2016 ; 7
(14
): 2117-2123
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Lymphangiogenesis in Classical Hodgkin Lymphoma - Preliminary Study with
Clinicopathological Correlations
#MMPMID27877228
Benharroch D
; Prinsloo I
; Gopas J
; Lazarev I
J Cancer
2016[]; 7
(14
): 2117-2123
PMID27877228
show ga
A role for lymphangiogenesis in metastatic breast and prostate cancers has been
suggested recently. The relevance of lymphangiogenesis in cancer as a rule, and
more specifically in classical Hodgkin lymphoma, is poorly understood in
comparison with that of angiogenesis. In a preliminary (pilot) study we have
investigated the role of lymphatic vessels growth in 19 cases of classical
Hodgkin lymphoma stained with the D2-40 (podoplanin) antibody. In each case,
three lymphatic vessels hot spots were scrutinized twice. Of the 57 hot spots
thus identified, we chose 15 at random for photography, microvessel counting and
image analysis. We determined the mean perimeter, surface area, major axis length
and complexity factor for each hot spot and correlated them with clinical and
biological features of classical Hodgkin lymphoma. No correlations were found
with clinical features. No associations were noted with the standard
immuno-markers of classical Hodgkin lymphoma. However, significant inverse
correlations were shown with pRb, BAX and I?B-? expression. The mean lymphatic
major axis length was inversely correlated with the complexity factor. Last, we
carried out an additional clinicopathological correlation of the expression of
pRb, BAX and I?B-? in a cohort of classical Hodgkin lymphoma patients previously
published.