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Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Biomed+Res+Int 2016 ; 2016 (ä): ä Nephropedia Template TP
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Long Noncoding RNA-LET Suppresses Tumor Growth and EMT in Lung Adenocarcinoma #MMPMID27896272
Liu B; Pan CF; He ZC; Wang J; Wang PL; Ma T; Xia Y; Chen YJ
Biomed Res Int 2016[]; 2016 (ä): ä PMID27896272show ga
Recently, many studies showed that long noncoding RNAs (lncRNAs) are involved in tumor progression. It is reported that lncRNA-LET is downregulated and has antitumor effect on several types of cancer. This study focuses on the role of lncRNA-LET on lung adenocarcinoma (LAC) progression. RT-PCR results indicated that frequent downregulation of lncRNA-LET in LAC tissues was related to clinicopathologic factors. lncRNA-LET knockdown significantly promoted LAC cell proliferation, invasion, and migration while lncRNA-LET overexpression obviously inhibited LAC cell proliferation, invasion, and migration, indicating a tumor inhibition of lncRNA-LET in LAC progression. Besides, lncRNA-LET inhibited EMT and negatively regulated Wnt/?-catenin pathway in part. Our study suggests that lncRNA-LET exhibits an important tumor-suppressive effect on LAC progression by inhibiting EMT and Wnt/?-catenin pathway, which provides potential therapeutic targets for LAC.