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10.1155/2016/4693471

http://scihub22266oqcxt.onion/10.1155/2016/4693471
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C5118531!5118531!27896272
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suck abstract from ncbi


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pmid27896272      Biomed+Res+Int 2016 ; 2016 (ä): ä
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  • Long Noncoding RNA-LET Suppresses Tumor Growth and EMT in Lung Adenocarcinoma #MMPMID27896272
  • Liu B; Pan CF; He ZC; Wang J; Wang PL; Ma T; Xia Y; Chen YJ
  • Biomed Res Int 2016[]; 2016 (ä): ä PMID27896272show ga
  • Recently, many studies showed that long noncoding RNAs (lncRNAs) are involved in tumor progression. It is reported that lncRNA-LET is downregulated and has antitumor effect on several types of cancer. This study focuses on the role of lncRNA-LET on lung adenocarcinoma (LAC) progression. RT-PCR results indicated that frequent downregulation of lncRNA-LET in LAC tissues was related to clinicopathologic factors. lncRNA-LET knockdown significantly promoted LAC cell proliferation, invasion, and migration while lncRNA-LET overexpression obviously inhibited LAC cell proliferation, invasion, and migration, indicating a tumor inhibition of lncRNA-LET in LAC progression. Besides, lncRNA-LET inhibited EMT and negatively regulated Wnt/?-catenin pathway in part. Our study suggests that lncRNA-LET exhibits an important tumor-suppressive effect on LAC progression by inhibiting EMT and Wnt/?-catenin pathway, which provides potential therapeutic targets for LAC.
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