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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Rheumatol+Rep
2014 ; 16
(12
): 467
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The presentation, assessment, pathogenesis, and treatment of calcinosis in
juvenile dermatomyositis
#MMPMID25366934
Hoeltzel MF
; Oberle EJ
; Robinson AB
; Agarwal A
; Rider LG
Curr Rheumatol Rep
2014[Dec]; 16
(12
): 467
PMID25366934
show ga
Calcinosis is one of the hallmark sequelae of juvenile dermatomyositis (JDM), and
despite recent progress in the therapy of JDM, dystrophic calcification still
occurs in approximately one third of patients. This review discusses our current,
albeit limited, understanding of risk factors for the development of calcinosis
in JDM, as well as approaches to assessment, and current views on its
pathogenesis. Anecdotal approaches to treating calcinosis associated with JDM,
including both anti-inflammatory therapies and agents aimed at inhibiting the
deposition of calcium hydroxyapatite, are reviewed. An improved understanding of
the pathogenesis of calcinosis, the establishment of standardized measurement
tools to assess calcinosis, and randomized controlled trials employing more
sensitive outcome measures are needed to develop efficacious therapies for this
often disabling complication.