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10.1039/c6cs00271d http://scihub22266oqcxt.onion/10.1039/c6cs00271d C5118097!5118097!27722328     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chem+Soc+Rev 2016 ; 45 (23): 6597-626 Nephropedia Template TP {{tp|p=27722328|t=2016. Reactive Oxygen Species Generating Systems Meeting Challenges of Photodynamic Cancer Therapy |pdf=|usr=}}{{27722328}} gab.com Text Reactive Oxygen Species Generating Systems Meeting Challenges of Photodynamic Cancer Therapy JO: Chem Soc Rev http://www.kidney.de/pget.php?&tw=1&pmid=27722328 #FOAvip Reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of synergistic effects between light, photosensitizer (PS) and oxygen, which greatly favor the spatiotemporal control of the treatment. This procedure has also evoked several unresolved challenges at different levels including (i) limited penetration depth of light restricts traditional PDT to only superficial tumours; (ii) oxygen reliance deprives PDT treatment of hypoxic tumours; (iii) light could complicate the phototherapeutic outcomes due to the concurrent heat generation; (iv) specific delivery of PSs to sub-cellular organelles for exerting effective toxicity remains an issue; and (v) side effects by undesirable white-light activation and self-catalysation of traditional PSs. Recent advances in nanotechnology and nanomedicine have provided new opportunities to develop ROS-generating systems through photodynamic or non-photodynamic procedures while tackling the challenges of current PDT approaches. In this review, we summarize the current status and discuss the possible opportunities of ROS generation for cancer therapy. We hope this review will spur pre-clinical research and clinical practice for ROS-mediated tumour treatment. Twit Text FOAVip Reactive Oxygen Species Generating Systems Meeting Challenges of Photodynamic Cancer Therapy ????Chem Soc Rev http://www.kidney.de/pget.php?&tw=1&pmid=27722328 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27722328 #FOAvip English Wikipedia <ref>{{Cite pmid|27722328}}</ref> Reactive Oxygen Species Generating Systems Meeting Challenges of Photodynamic Cancer Therapy #MMPMID27722328 Zhou Z; Song J; Nie L; Chen X Chem Soc Rev 2016[Nov]; 45 (23): 6597-626 PMID27722328show ga Reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of synergistic effects between light, photosensitizer (PS) and oxygen, which greatly favor the spatiotemporal control of the treatment. This procedure has also evoked several unresolved challenges at different levels including (i) limited penetration depth of light restricts traditional PDT to only superficial tumours; (ii) oxygen reliance deprives PDT treatment of hypoxic tumours; (iii) light could complicate the phototherapeutic outcomes due to the concurrent heat generation; (iv) specific delivery of PSs to sub-cellular organelles for exerting effective toxicity remains an issue; and (v) side effects by undesirable white-light activation and self-catalysation of traditional PSs. Recent advances in nanotechnology and nanomedicine have provided new opportunities to develop ROS-generating systems through photodynamic or non-photodynamic procedures while tackling the challenges of current PDT approaches. In this review, we summarize the current status and discuss the possible opportunities of ROS generation for cancer therapy. We hope this review will spur pre-clinical research and clinical practice for ROS-mediated tumour treatment. äReactive Oxygen Species Generating Systems Meeting Challenges of Photo(epmc).pdf DeepDyve Pubget Overpricing