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10.2147/DDDT.S103534

http://scihub22266oqcxt.onion/10.2147/DDDT.S103534
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C5117890!5117890!27895464
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suck abstract from ncbi


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pmid27895464      Drug+Des+Devel+Ther 2016 ; 10 (ä): 3747-54
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  • Selexipag in the treatment of pulmonary arterial hypertension: design, development, and therapy #MMPMID27895464
  • Hardin EA; Chin KM
  • Drug Des Devel Ther 2016[]; 10 (ä): 3747-54 PMID27895464show ga
  • Pulmonary arterial hypertension is characterized by abnormalities in the small pulmonary arteries including increased vasoconstriction, vascular remodeling, proliferation of smooth muscle cells, and in situ thrombosis. Selexipag, a novel, oral prostacyclin receptor agonist, has been shown to improve hemodynamics in a phase II clinical trial and reduce clinical worsening in a large phase III clinical trial involving patients with pulmonary arterial hypertension. In this paper, we describe the prostacyclin signaling pathway, currently available oral prostanoid medications, and the development and clinical use of selexipag.
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