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10.1038/ni.3559 http://scihub22266oqcxt.onion/10.1038/ni.3559 C5117833!5117833 !27668798     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27668798 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Immunol 2016 ; 17 (11 ): 1312-1321 Nephropedia Template TP {{tp|p=27668798 |t=2016. The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells |pdf=|usr=}}{{27668798 }} gab.com Text The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27668798 #FOAvip Hematopoietic stem cells (HSCs) are dormant in the bone marrow and can be activated in response to diverse stresses to replenish all blood cell types. We identified the ubiquitin ligase Huwe1 as a crucial regulator of HSC function via its post-translational control of the oncoprotein N-myc (encoded by Mycn). We found Huwe1 to be essential for HSC self-renewal, quiescence and lymphoid-fate specification in mice. Through the use of a fluorescent fusion allele (Mycn(M)), we observed that N-myc expression was restricted to the most immature, multipotent stem and progenitor populations. N-myc expression was upregulated in response to stress or following loss of Huwe1, which led to increased proliferation and stem-cell exhaustion. Mycn depletion reversed most of these phenotypes in vivo, which suggested that the attenuation of N-myc by Huwe1 is essential for reestablishing homeostasis following stress. Twit Text FOAVip The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27668798 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27668798 #FOAvip English Wikipedia <ref>{{Cite pmid|27668798 }}</ref> The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells #MMPMID27668798 King B ; Boccalatte F ; Moran-Crusio K ; Wolf E ; Wang J ; Kayembe C ; Lazaris C ; Yu X ; Aranda-Orgilles B ; Lasorella A ; Aifantis I Nat Immunol 2016[Nov]; 17 (11 ): 1312-1321 PMID27668798 show ga Hematopoietic stem cells (HSCs) are dormant in the bone marrow and can be activated in response to diverse stresses to replenish all blood cell types. We identified the ubiquitin ligase Huwe1 as a crucial regulator of HSC function via its post-translational control of the oncoprotein N-myc (encoded by Mycn). We found Huwe1 to be essential for HSC self-renewal, quiescence and lymphoid-fate specification in mice. Through the use of a fluorescent fusion allele (Mycn(M)), we observed that N-myc expression was restricted to the most immature, multipotent stem and progenitor populations. N-myc expression was upregulated in response to stress or following loss of Huwe1, which led to increased proliferation and stem-cell exhaustion. Mycn depletion reversed most of these phenotypes in vivo, which suggested that the attenuation of N-myc by Huwe1 is essential for reestablishing homeostasis following stress. |Animals [MESH] |Cell Cycle/genetics [MESH] |Cell Differentiation/*genetics [MESH] |Cell Line [MESH] |Cell Lineage/*genetics [MESH] |Cell Self Renewal/genetics [MESH] |Cluster Analysis [MESH] |Gene Expression Profiling [MESH] |Genes, myc [MESH] |Hematopoietic Stem Cells/*cytology/*metabolism [MESH] |Lymphocytes/cytology/*metabolism [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Mice, Transgenic [MESH] |Protein Stability [MESH] |Proto-Oncogene Proteins c-myc/genetics/metabolism [MESH] |Stress, Physiological [MESH] |Transcription, Genetic [MESH] |Tumor Suppressor Proteins [MESH]The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid comm(epmc).pdf DeepDyve Pubget Overpricing