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10.1038/nchembio.2207 http://scihub22266oqcxt.onion/10.1038/nchembio.2207 C5117632!5117632!27748750     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Chem+Biol 2016 ; 12 (12): 1004-6 Nephropedia Template TP {{tp|p=27748750|t=2016. Discovery of MRSA active antibiotics using primary sequence from the human microbiome |pdf=|usr=}}{{27748750}} gab.com Text Discovery of MRSA active antibiotics using primary sequence from the human microbiome JO: Nat Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=27748750 #FOAvip Here, we present a natural product discovery approach whereby structures are bioinformatically predicted from primary sequence and produced by chemical synthesis (synthetic-bioinformatic natural products, syn-BNPs), circumventing the need for bacterial culture and gene expression. When applied to nonribosomal peptide synthetase gene clusters from human-associated bacteria we identified the humimycins. These antibiotics inhibit lipid II flippase and potentiate ?-lactam activity against methicillin-resistant Staphylococcus aureus in mice, potentially providing a new treatment regimen. Twit Text FOAVip Discovery of MRSA active antibiotics using primary sequence from the human microbiome ????Nat Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=27748750 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27748750 #FOAvip English Wikipedia <ref>{{Cite pmid|27748750}}</ref> Discovery of MRSA active antibiotics using primary sequence from the human microbiome #MMPMID27748750 Chu J; Vila-Farres X; Inoyama D; Ternei M; Cohen LJ; Gordon EA; Reddy BVB; Charlop-Powers Z; Zebroski HA; Gallardo-Macias R; Jaskowski M; Satish S; Park S; Perlin DS; Freundlich JS; Brady SF Nat Chem Biol 2016[Dec]; 12 (12): 1004-6 PMID27748750show ga Here, we present a natural product discovery approach whereby structures are bioinformatically predicted from primary sequence and produced by chemical synthesis (synthetic-bioinformatic natural products, syn-BNPs), circumventing the need for bacterial culture and gene expression. When applied to nonribosomal peptide synthetase gene clusters from human-associated bacteria we identified the humimycins. These antibiotics inhibit lipid II flippase and potentiate ?-lactam activity against methicillin-resistant Staphylococcus aureus in mice, potentially providing a new treatment regimen. äDiscovery of MRSA active antibiotics using primary sequence from the h(epmc).pdf DeepDyve Pubget Overpricing