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10.1242/dev.138917 http://scihub22266oqcxt.onion/10.1242/dev.138917 C5117142!5117142!27633991     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Development 2016 ; 143 (21): 3944-55 Nephropedia Template TP {{tp|p=27633991|t=2016. Members of the Rusc protein family interact with Sufu and inhibit vertebrate Hedgehog signaling |pdf=|usr=}}{{27633991}} gab.com Text Members of the Rusc protein family interact with Sufu and inhibit vertebrate Hedgehog signaling JO: Development http://www.kidney.de/pget.php?&tw=1&pmid=27633991 #FOAvip Hedgehog (Hh) signaling is fundamentally important for development and adult tissue homeostasis. It is well established that in vertebrates Sufu directly binds and inhibits Gli proteins, the downstream mediators of Hh signaling. However, it is unclear how the inhibitory function of Sufu towards Gli is regulated. Here we report that the Rusc family of proteins, the biological functions of which are poorly understood, form a heterotrimeric complex with Sufu and Gli. Upon Hh signaling, Rusc is displaced from this complex, followed by dissociation of Gli from Sufu. In mammalian fibroblast cells, knockdown of Rusc2 potentiates Hh signaling by accelerating signaling-induced dissociation of the Sufu-Gli protein complexes. In Xenopus embryos, knockdown of Rusc1 or overexpression of a dominant-negative Rusc enhances Hh signaling during eye development, leading to severe eye defects. Our study thus uncovers a novel regulatory mechanism controlling the response of cells to Hh signaling in vertebrates. Twit Text FOAVip Members of the Rusc protein family interact with Sufu and inhibit vertebrate Hedgehog signaling ????Development http://www.kidney.de/pget.php?&tw=1&pmid=27633991 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27633991 #FOAvip English Wikipedia <ref>{{Cite pmid|27633991}}</ref> Members of the Rusc protein family interact with Sufu and inhibit vertebrate Hedgehog signaling #MMPMID27633991 Jin Z; Schwend T; Fu J; Bao Z; Liang J; Zhao H; Mei W; Yang J Development 2016[Nov]; 143 (21): 3944-55 PMID27633991show ga Hedgehog (Hh) signaling is fundamentally important for development and adult tissue homeostasis. It is well established that in vertebrates Sufu directly binds and inhibits Gli proteins, the downstream mediators of Hh signaling. However, it is unclear how the inhibitory function of Sufu towards Gli is regulated. Here we report that the Rusc family of proteins, the biological functions of which are poorly understood, form a heterotrimeric complex with Sufu and Gli. Upon Hh signaling, Rusc is displaced from this complex, followed by dissociation of Gli from Sufu. In mammalian fibroblast cells, knockdown of Rusc2 potentiates Hh signaling by accelerating signaling-induced dissociation of the Sufu-Gli protein complexes. In Xenopus embryos, knockdown of Rusc1 or overexpression of a dominant-negative Rusc enhances Hh signaling during eye development, leading to severe eye defects. Our study thus uncovers a novel regulatory mechanism controlling the response of cells to Hh signaling in vertebrates. äMembers of the Rusc protein family interact with Sufu and inhibit vert(epmc).pdf DeepDyve Pubget Overpricing