Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.pharmthera.2016.05.001 http://scihub22266oqcxt.onion/10.1016/j.pharmthera.2016.05.001 C5116389!5116389!27179744     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27179744&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pharmacol+Ther 2016 ; 165 (ä): 1-13 Nephropedia Template TP {{tp|p=27179744|t=2016. Multifunctional roles of PKC?: Opportunities for targeted therapy in human disease |pdf=|usr=}}{{27179744}} gab.com Text Multifunctional roles of PKC : Opportunities for targeted therapy in human disease JO: Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=27179744 #FOAvip The serine?threonine protein kinase, protein kinase C-? (PKC?), is emerging as a bi-functional regulator of cell death and proliferation. Studies in PKC??/? mice have confirmed a pro-apoptotic role for this kinase in response to DNA damage and a tumor promoter role in some oncogenic contexts. In non-transformed cells, inhibition of PKC? suppresses the release of cytochrome c and caspase activation, indicating a function upstream of apoptotic pathways. Data from PKC??/? mice demonstrate a role for PKC? in the execution of DNA damage-induced and physiologic apoptosis. This has led to the important finding that inhibitors of PKC? can be used therapeutically to reduce irradiation and chemotherapy-induced toxicity. By contrast, PKC? is a tumor promoter in mouse models of mammary gland and lung cancer, and increased PKC? expression is a negative prognostic indicator in Her2+ and other subtypes of human breast cancer. Understanding how these distinct functions of PKC? are regulated is critical for the design of therapeutics to target this pathway. This review will discuss what is currently known about biological roles of PKC? and prospects for targeting PKC? in human disease. Twit Text FOAVip Multifunctional roles of PKC : Opportunities for targeted therapy in human disease ????Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=27179744 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27179744 #FOAvip English Wikipedia <ref>{{Cite pmid|27179744}}</ref> Multifunctional roles of PKC?: Opportunities for targeted therapy in human disease #MMPMID27179744 Reyland ME; Jones DN Pharmacol Ther 2016[Sep]; 165 (ä): 1-13 PMID27179744show ga The serine?threonine protein kinase, protein kinase C-? (PKC?), is emerging as a bi-functional regulator of cell death and proliferation. Studies in PKC??/? mice have confirmed a pro-apoptotic role for this kinase in response to DNA damage and a tumor promoter role in some oncogenic contexts. In non-transformed cells, inhibition of PKC? suppresses the release of cytochrome c and caspase activation, indicating a function upstream of apoptotic pathways. Data from PKC??/? mice demonstrate a role for PKC? in the execution of DNA damage-induced and physiologic apoptosis. This has led to the important finding that inhibitors of PKC? can be used therapeutically to reduce irradiation and chemotherapy-induced toxicity. By contrast, PKC? is a tumor promoter in mouse models of mammary gland and lung cancer, and increased PKC? expression is a negative prognostic indicator in Her2+ and other subtypes of human breast cancer. Understanding how these distinct functions of PKC? are regulated is critical for the design of therapeutics to target this pathway. This review will discuss what is currently known about biological roles of PKC? and prospects for targeting PKC? in human disease. äMultifunctional roles of PKC?: Opportunities for targeted therapy in h(epmc).pdf DeepDyve Pubget Overpricing