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Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Hepat+Mon 2016 ; 16 (10): ä Nephropedia Template TP
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The Long-Term Outcomes for Patients with Budd-Chiari Syndrome Caused by Behcet?s Disease: A Case Series on the Results, from Cirrhosis to Death #MMPMID27882061
Cansu DU; Temel T; Erturk A; Kasifoglu T; Acu B; Korkmaz C
Hepat Mon 2016[Oct]; 16 (10): ä PMID27882061show ga
Background: Budd-Chiari syndrome, which is a rare complication of Behcet?s disease, carries a high mortality rate. Objectives: The aim of the study was to present our long-term follow up experience with patients suffering from Budd-Chiari syndrome due to Behcet?s disease. Methods: The records of 402 patients with Behcet?s disease were evaluated retrospectively. To facilitate detection of the long-term complications caused by Budd-Chiari syndrome, the patients were evaluated via physical examinations, laboratory tests, imaging modalities, and endoscopy results. Results: The data for 402 patients diagnosed with Behcet?s disease, who were followed up at our hospital over 16 years, were analyzed retrospectively. Five of these 402 patients (1.2%) were diagnosed as having Budd-Chiari syndrome. The patients with Budd-Chiari syndrome were aged between 23 and 54, and all five were male. The interval between the onset of Behcet?s disease and the development of Budd-Chiari syndrome ranged from 1 to 8 years. All the patients had combined venous occlusion (affecting the hepatic vein and inferior vena cava). Portal venous thrombosis was detected in only one patient (Case 1), who died 1 month after the diagnosis of Budd-Chiari syndrome. The survival time for the other four patients after the diagnosis of Budd-Chiari syndrome ranged from 4 to 16 years. During the long-term follow-up, hepatic masses were detected via radiological surveillance in Case 3 (in the form of large regenerative nodules) and Case 4 (nodular regenerative hyperplasia and cirrhosis). Conclusions: In our study, portal venous thrombosis was detected in the patient who died during the acute period only. A study including large numbers of Budd-Chiari-syndrome patients with Behcet?s disease and portal venous thrombosis would be helpful to determine the prognostic significance of portal venous thrombosis in Budd-Chiari-syndrome patients with Behcet?s disease. In addition, patients should be monitored regularly for the development of hepatic masses via a long-term surveillance program.