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10.1016/j.cell.2016.10.022 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.10.022 C5115957!5115957!27839867     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2016 ; 167 (5): 1296-1309.e10 Nephropedia Template TP {{tp|p=27839867|t=2016. Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions |pdf=|usr=}}{{27839867}} gab.com Text Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=27839867 #FOAvip The ability of cells to count and remember their divisions could underlie many alterations that occur during development, aging, and disease. We tracked the cumulative divisional history of slow-cycling hematopoietic stem cells (HSCs) throughout adult life. This revealed a fraction of rarely dividing HSCs that contained all the long-term HSC (LT-HSC) activity within the aging HSC compartment. During adult life, this population asynchronously completes four traceable symmetric self-renewal divisions to expand its size before entering a state of dormancy. We show that the mechanism of expansion involves progressively lengthening periods between cell divisions, with long-term regenerative potential lost upon a fifth division. Our data also show that age-related phenotypic changes within the HSC compartment are divisional history dependent. These results suggest that HSCs accumulate discrete memory stages over their divisional history and provide evidence for the role of cellular memory in HSC aging. Twit Text FOAVip Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=27839867 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27839867 #FOAvip English Wikipedia <ref>{{Cite pmid|27839867}}</ref> Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions #MMPMID27839867 Bernitz JM; Kim HS; MacArthur B; Sieburg H; Moore K Cell 2016[Nov]; 167 (5): 1296-1309.e10 PMID27839867show ga The ability of cells to count and remember their divisions could underlie many alterations that occur during development, aging, and disease. We tracked the cumulative divisional history of slow-cycling hematopoietic stem cells (HSCs) throughout adult life. This revealed a fraction of rarely dividing HSCs that contained all the long-term HSC (LT-HSC) activity within the aging HSC compartment. During adult life, this population asynchronously completes four traceable symmetric self-renewal divisions to expand its size before entering a state of dormancy. We show that the mechanism of expansion involves progressively lengthening periods between cell divisions, with long-term regenerative potential lost upon a fifth division. Our data also show that age-related phenotypic changes within the HSC compartment are divisional history dependent. These results suggest that HSCs accumulate discrete memory stages over their divisional history and provide evidence for the role of cellular memory in HSC aging. äHematopoietic Stem Cells Count and Remember Self-Renewal Divisions (epmc).pdf DeepDyve Pubget Overpricing