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10.7554/eLife.20492 http://scihub22266oqcxt.onion/10.7554/eLife.20492 C5115872!5115872!27815945     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2016 ; 5 (ä): ä Nephropedia Template TP {{tp|p=27815945|t=2016. A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda |pdf=|usr=}}{{27815945}} gab.com Text A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=27815945 #FOAvip Evolutionary theory hypothesizes that intermediate virulence maximizes pathogen fitness as a result of a trade-off between virulence and transmission, but empirical evidence remains scarce. We bridge this gap using data from a large and long-standing HIV-1 prospective cohort, in Uganda. We use an epidemiological-evolutionary model parameterised with this data to derive evolutionary predictions based on analysis and detailed individual-based simulations. We robustly predict stabilising selection towards a low level of virulence, and rapid attenuation of the virus. Accordingly, set-point viral load, the most common measure of virulence, has declined in the last 20 years. Our model also predicts that subtype A is slowly outcompeting subtype D, with both subtypes becoming less virulent, as observed in the data. Reduction of set-point viral loads should have resulted in a 20% reduction in incidence, and a three years extension of untreated asymptomatic infection, increasing opportunities for timely treatment of infected individuals.DOI:http://dx.doi.org/10.7554/eLife.20492.001 Twit Text FOAVip A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=27815945 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27815945 #FOAvip English Wikipedia <ref>{{Cite pmid|27815945}}</ref> A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda #MMPMID27815945 Blanquart F; Grabowski MK; Herbeck J; Nalugoda F; Serwadda D; Eller MA; Robb ML; Gray R; Kigozi G; Laeyendecker O; Lythgoe KA; Nakigozi G; Quinn TC; Reynolds SJ; Wawer MJ; Fraser C eLife 2016[]; 5 (ä): ä PMID27815945show ga Evolutionary theory hypothesizes that intermediate virulence maximizes pathogen fitness as a result of a trade-off between virulence and transmission, but empirical evidence remains scarce. We bridge this gap using data from a large and long-standing HIV-1 prospective cohort, in Uganda. We use an epidemiological-evolutionary model parameterised with this data to derive evolutionary predictions based on analysis and detailed individual-based simulations. We robustly predict stabilising selection towards a low level of virulence, and rapid attenuation of the virus. Accordingly, set-point viral load, the most common measure of virulence, has declined in the last 20 years. Our model also predicts that subtype A is slowly outcompeting subtype D, with both subtypes becoming less virulent, as observed in the data. Reduction of set-point viral loads should have resulted in a 20% reduction in incidence, and a three years extension of untreated asymptomatic infection, increasing opportunities for timely treatment of infected individuals.DOI:http://dx.doi.org/10.7554/eLife.20492.001 äA transmission-virulence evolutionary trade-off explains attenuation o(epmc).pdf DeepDyve Pubget Overpricing