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10.1158/2326-6066.CIR-16-0042 http://scihub22266oqcxt.onion/10.1158/2326-6066.CIR-16-0042 C5115633!5115633 !27688020     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27688020 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Immunol+Res 2016 ; 4 (11 ): 948-958 Nephropedia Template TP {{tp|p=27688020 |t=2016. Systemic GM-CSF Recruits Effector T Cells into the Tumor Microenvironment in Localized Prostate Cancer |pdf=|usr=}}{{27688020 }} gab.com Text Systemic GM-CSF Recruits Effector T Cells into the Tumor Microenvironment in Localized Prostate Cancer JO: Cancer Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=27688020 #FOAvip Granulocytic-macrophage colony-stimulating factor (GM-CSF) is used as an adjuvant in cancer vaccine trials and has the potential to enhance antitumor efficacy with immunotherapy; however, its immunologic effects are not fully understood. Here, we report results from a phase I study of neoadjuvant GM-CSF in patients with localized prostate cancer undergoing radical prostatectomy. Patients received subcutaneous injections of GM-CSF (250 ?g/m(2)/day) daily for 2 weeks (cohort 1; n = 6), 3 weeks (cohort 2; n = 6), or 4 weeks (cohort 3; n = 6). Treatment was well tolerated with all grade 1 or 2 adverse events. Two patients had a decline in prostate-specific antigen (PSA) of more than 50%. GM-CSF treatment increased the numbers of circulating mature myeloid dendritic cells, proliferating conventional CD4 T cells, proliferating CD8 T cells, and to a lesser magnitude FoxP3(+) regulatory CD4 T cells. Although GM-CSF treatment did not augment antigen-presenting cell localization to the prostate, treatment was associated with recruitment of CD8(+) T cells to the tumor. These results suggest that systemic GM-CSF can modulate T-cell infiltration in the tumor microenvironment. Cancer Immunol Res; 4(11); 948-58. ©2016 AACR. Twit Text FOAVip Systemic GM-CSF Recruits Effector T Cells into the Tumor Microenvironment in Localized Prostate Cancer ????Cancer Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=27688020 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27688020 #FOAvip English Wikipedia <ref>{{Cite pmid|27688020 }}</ref> Systemic GM-CSF Recruits Effector T Cells into the Tumor Microenvironment in Localized Prostate Cancer #MMPMID27688020 Wei XX ; Chan S ; Kwek S ; Lewis J ; Dao V ; Zhang L ; Cooperberg MR ; Ryan CJ ; Lin AM ; Friedlander TW ; Rini B ; Kane C ; Simko JP ; Carroll PR ; Small EJ ; Fong L Cancer Immunol Res 2016[Nov]; 4 (11 ): 948-958 PMID27688020 show ga Granulocytic-macrophage colony-stimulating factor (GM-CSF) is used as an adjuvant in cancer vaccine trials and has the potential to enhance antitumor efficacy with immunotherapy; however, its immunologic effects are not fully understood. Here, we report results from a phase I study of neoadjuvant GM-CSF in patients with localized prostate cancer undergoing radical prostatectomy. Patients received subcutaneous injections of GM-CSF (250 ?g/m(2)/day) daily for 2 weeks (cohort 1; n = 6), 3 weeks (cohort 2; n = 6), or 4 weeks (cohort 3; n = 6). Treatment was well tolerated with all grade 1 or 2 adverse events. Two patients had a decline in prostate-specific antigen (PSA) of more than 50%. GM-CSF treatment increased the numbers of circulating mature myeloid dendritic cells, proliferating conventional CD4 T cells, proliferating CD8 T cells, and to a lesser magnitude FoxP3(+) regulatory CD4 T cells. Although GM-CSF treatment did not augment antigen-presenting cell localization to the prostate, treatment was associated with recruitment of CD8(+) T cells to the tumor. These results suggest that systemic GM-CSF can modulate T-cell infiltration in the tumor microenvironment. Cancer Immunol Res; 4(11); 948-58. ©2016 AACR. |Adjuvants, Immunologic/*administration & dosage/adverse effects [MESH] |Aged [MESH] |Antigen-Presenting Cells/immunology/metabolism [MESH] |Biomarkers [MESH] |Granulocyte-Macrophage Colony-Stimulating Factor/*administration & dosage/adverse effects [MESH] |Humans [MESH] |Immunotherapy [MESH] |Lymphocytes, Tumor-Infiltrating/drug effects/immunology/metabolism [MESH] |Male [MESH] |Middle Aged [MESH] |Neoadjuvant Therapy [MESH] |Neoplasm Grading [MESH] |Neoplasm Staging [MESH] |Prostatic Neoplasms/*immunology/pathology/*therapy [MESH] |T-Lymphocyte Subsets/*drug effects/*immunology [MESH] |Treatment Outcome [MESH]Systemic GM-CSF Recruits Effector T Cells into the Tumor Microenvironm(epmc).pdf DeepDyve Pubget Overpricing