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10.1186/s13059-016-1107-9 http://scihub22266oqcxt.onion/10.1186/s13059-016-1107-9 C5114767!5114767!27855690     free     free     free       Genome+Biol 2016 ; 17 (ä): ä Nephropedia Template TP {{tp|p=27855690|t=2016. The continuum of causality in human genetic disorders |pdf=|usr=}}{{27855690}} gab.com Text The continuum of causality in human genetic disorders JO: Genome Biol http://www.kidney.de/pget.php?&tw=1&pmid=27855690 #FOAvip Studies of human genetic disorders have traditionally followed a reductionist paradigm. Traits are defined as Mendelian or complex based on family pedigree and population data, whereas alleles are deemed rare, common, benign, or deleterious based on their population frequencies. The availability of exome and genome data, as well as gene and allele discovery for various conditions, is beginning to challenge classic definitions of genetic causality. Here, I discuss recent advances in our understanding of the overlap between rare and complex diseases and the context-dependent effect of both rare and common alleles that underscores the need for revising the traditional categorizations of genetic traits. Twit Text FOAVip The continuum of causality in human genetic disorders ????Genome Biol http://www.kidney.de/pget.php?&tw=1&pmid=27855690 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27855690 #FOAvip English Wikipedia <ref>{{Cite pmid|27855690}}</ref> The continuum of causality in human genetic disorders #MMPMID27855690 Katsanis N Genome Biol 2016[]; 17 (ä): ä PMID27855690show ga Studies of human genetic disorders have traditionally followed a reductionist paradigm. Traits are defined as Mendelian or complex based on family pedigree and population data, whereas alleles are deemed rare, common, benign, or deleterious based on their population frequencies. The availability of exome and genome data, as well as gene and allele discovery for various conditions, is beginning to challenge classic definitions of genetic causality. Here, I discuss recent advances in our understanding of the overlap between rare and complex diseases and the context-dependent effect of both rare and common alleles that underscores the need for revising the traditional categorizations of genetic traits. äThe continuum of causality in human genetic disorders (epmc).pdf DeepDyve Pubget Overpricing