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10.1038/ncomms13441 http://scihub22266oqcxt.onion/10.1038/ncomms13441 C5114608!5114608 !27834383     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27834383 &cmd=llinks): Failed to open stream: HTTP request failed! 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Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding A? plaques by iGluSnFR two-photon imaging |pdf=|usr=}}{{27834383 }} gab.com Text Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding A plaques by iGluSnFR two-photon imaging JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27834383 #FOAvip Amyloid-? (A?) plaques, a hallmark of Alzheimer's disease (AD), are surrounded by regions of neuronal and glial hyperactivity. We use in vivo two-photon and wide-field imaging of the glutamate sensor iGluSnFR to determine whether pathological changes in glutamate dynamics in the immediate vicinity of A? deposits in APPPS1 transgenic mice could alter neuronal activity in this microenvironment. In regions close to A? plaques chronic states of high spontaneous glutamate fluctuations are observed and the timing of glutamate responses evoked by sensory stimulation exhibit slower decay rates in two cortical brain areas. GLT-1 expression is reduced around A? plaques and upregulation of GLT-1 expression and activity by ceftriaxone partially restores glutamate dynamics to values in control regions. We conclude that the toxic microenvironment surrounding A? plaques results, at least partially, from enhanced glutamate levels and that pharmacologically increasing GLT-1 expression and activity may be a new target for early therapeutic intervention. Twit Text FOAVip Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding A plaques by iGluSnFR two-photon imaging ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27834383 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27834383 #FOAvip English Wikipedia <ref>{{Cite pmid|27834383 }}</ref> Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding A? plaques by iGluSnFR two-photon imaging #MMPMID27834383 Hefendehl JK ; LeDue J ; Ko RW ; Mahler J ; Murphy TH ; MacVicar BA Nat Commun 2016[Nov]; 7 (ä): 13441 PMID27834383 show ga Amyloid-? (A?) plaques, a hallmark of Alzheimer's disease (AD), are surrounded by regions of neuronal and glial hyperactivity. We use in vivo two-photon and wide-field imaging of the glutamate sensor iGluSnFR to determine whether pathological changes in glutamate dynamics in the immediate vicinity of A? deposits in APPPS1 transgenic mice could alter neuronal activity in this microenvironment. In regions close to A? plaques chronic states of high spontaneous glutamate fluctuations are observed and the timing of glutamate responses evoked by sensory stimulation exhibit slower decay rates in two cortical brain areas. GLT-1 expression is reduced around A? plaques and upregulation of GLT-1 expression and activity by ceftriaxone partially restores glutamate dynamics to values in control regions. We conclude that the toxic microenvironment surrounding A? plaques results, at least partially, from enhanced glutamate levels and that pharmacologically increasing GLT-1 expression and activity may be a new target for early therapeutic intervention. |Amino Acid Transport System X-AG/*metabolism [MESH] |Amyloid beta-Peptides/*metabolism [MESH] |Amyloid beta-Protein Precursor/*metabolism [MESH] |Animals [MESH] |Ceftriaxone [MESH] |Diagnostic Imaging/*methods [MESH] |Glutamic Acid [MESH] |Mice [MESH] |Mice, Transgenic [MESH]Mapping synaptic glutamate transporter dysfunction in vivo to regions (epmc).pdf DeepDyve Pubget Overpricing