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10.1182/blood-2016-06-716738

http://scihub22266oqcxt.onion/10.1182/blood-2016-06-716738
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C5114486!5114486!27856471
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suck abstract from ncbi


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pmid27856471      Blood 2016 ; 128 (20): 2395-402
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  • Role of the intestinal mucosa in acute gastrointestinal GVHD #MMPMID27856471
  • Peled JU; Hanash AM; Jenq RR
  • Blood 2016[Nov]; 128 (20): 2395-402 PMID27856471show ga
  • Intestinal graft-versus-host disease (GVHD) remains a significant obstacle to the success of allogeneic hematopoietic cell transplantation. The intestinal mucosa comprises the inner lining of the intestinal tract and maintains close proximity with commensal microbes that reside within the intestinal lumen. Recent advances have significantly improved our understanding of the interactions between the intestinal mucosa and the enteric microbiota. Changes in host mucosal tissue and commensals posttransplant have been actively investigated, and provocative insights into mucosal immunity and the enteric microbiota are now being translated into clinical trials of novel approaches for preventing and treating acute GVHD. In this review, we summarize recent findings related to aspects of the intestinal mucosa during acute GVHD.
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