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10.1074/jbc.M116.743815 http://scihub22266oqcxt.onion/10.1074/jbc.M116.743815 C5114405!5114405!27733681     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2016 ; 291 (47): 24517-27 Nephropedia Template TP {{tp|p=27733681|t=2016. Vitamin B6 Prevents IL-1? Protein Production by Inhibiting NLRP3 Inflammasome Activation* |pdf=|usr=}}{{27733681}} gab.com Text Vitamin B6 Prevents IL-1 Protein Production by Inhibiting NLRP3 Inflammasome Activation* JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27733681 #FOAvip Vitamin B6 includes six water-soluble vitamers: pyridoxal (PL), pyridoxamine (PM), pyridoxine (PN), and their phosphorylated forms. Pyridoxal 5?-phosphate (PLP) is an important cofactor for many metabolic enzymes. Several lines of evidence demonstrate that blood levels of PLP are significantly lower in patients with inflammation than in control subjects and that vitamin B6 has anti-inflammatory effects, with therapeutic potential for a variety of inflammatory diseases. Although one of our group previously demonstrated that PL inhibits the NF-?B pathway, the molecular mechanism by which vitamin B6 suppresses inflammation is not well understood. Here, we showed that both PL and PLP suppressed the expression of cytokine genes in macrophages by inhibiting Toll-like receptor (TLR)-mediated TAK1 phosphorylation and the subsequent NF-?B and JNK activation. Furthermore, PL and PLP abolished NLRP3-dependent caspase-1 processing and the subsequent secretion of mature IL-1? and IL-18 in LPS-primed macrophages. In contrast, PM and PN had little effect on IL-1? production. PLP, but not PL, markedly reduced the production of mitochondrial reactive oxygen species (ROS) in peritoneal macrophages. Importantly, PL and PLP reduced IL-1? production induced by LPS and ATP, or by LPS alone, in mice. Moreover, PL and PLP protected mice from lethal endotoxic shock. Collectively, these findings reveal novel anti-inflammatory activities for vitamin B6 and suggest its potential for preventing inflammatory diseases driven by the NLRP3 inflammasome. Twit Text FOAVip Vitamin B6 Prevents IL-1 Protein Production by Inhibiting NLRP3 Inflammasome Activation* ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27733681 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27733681 #FOAvip English Wikipedia <ref>{{Cite pmid|27733681}}</ref> Vitamin B6 Prevents IL-1? Protein Production by Inhibiting NLRP3 Inflammasome Activation* #MMPMID27733681 Zhang P; Tsuchiya K; Kinoshita T; Kushiyama H; Suidasari S; Hatakeyama M; Imura H; Kato N; Suda T J Biol Chem 2016[Nov]; 291 (47): 24517-27 PMID27733681show ga Vitamin B6 includes six water-soluble vitamers: pyridoxal (PL), pyridoxamine (PM), pyridoxine (PN), and their phosphorylated forms. Pyridoxal 5?-phosphate (PLP) is an important cofactor for many metabolic enzymes. Several lines of evidence demonstrate that blood levels of PLP are significantly lower in patients with inflammation than in control subjects and that vitamin B6 has anti-inflammatory effects, with therapeutic potential for a variety of inflammatory diseases. Although one of our group previously demonstrated that PL inhibits the NF-?B pathway, the molecular mechanism by which vitamin B6 suppresses inflammation is not well understood. Here, we showed that both PL and PLP suppressed the expression of cytokine genes in macrophages by inhibiting Toll-like receptor (TLR)-mediated TAK1 phosphorylation and the subsequent NF-?B and JNK activation. Furthermore, PL and PLP abolished NLRP3-dependent caspase-1 processing and the subsequent secretion of mature IL-1? and IL-18 in LPS-primed macrophages. In contrast, PM and PN had little effect on IL-1? production. PLP, but not PL, markedly reduced the production of mitochondrial reactive oxygen species (ROS) in peritoneal macrophages. Importantly, PL and PLP reduced IL-1? production induced by LPS and ATP, or by LPS alone, in mice. Moreover, PL and PLP protected mice from lethal endotoxic shock. Collectively, these findings reveal novel anti-inflammatory activities for vitamin B6 and suggest its potential for preventing inflammatory diseases driven by the NLRP3 inflammasome. äVitamin B6 Prevents IL-1? Protein Production by Inhibiting NLRP3 Infla(epmc).pdf DeepDyve Pubget Overpricing