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10.1074/jbc.M116.755850 http://scihub22266oqcxt.onion/10.1074/jbc.M116.755850 C5114398!5114398 !27703003     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27703003 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2016 ; 291 (47 ): 24418-24430 Nephropedia Template TP {{tp|p=27703003 |t=2016. SUMO Modification Reverses Inhibitory Effects of Smad Nuclear Interacting Protein-1 in TGF-? Responses |pdf=|usr=}}{{27703003 }} gab.com Text SUMO Modification Reverses Inhibitory Effects of Smad Nuclear Interacting Protein-1 in TGF- Responses JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27703003 #FOAvip SNIP1 (Smad nuclear interacting protein 1) is a transcription repressor for the TGF-? and NF-?B signaling pathways through disrupting the recruitment of co-activator p300. However, it is unclear how the functions of SNIP1 in the TGF-? signaling pathway are controlled. Our present studies show that SNIP1 is covalently modified by small ubiquitin-like modifier (SUMO) in vitro and in vivo at three lysine sites: Lys(5), Lys(30), and Lys(108), with Lys(30) being the major SUMO modification site. SUMOylation of SNIP1 is enhanced by SUMO E3 ligase PIAS proteins and inhibited by SUMO proteases SENP1/2. Furthermore, we find that SUMOylation of SNIP1 attenuates its inhibitory effect in TGF-? signaling because the SUMO-conjugated form of SNIP1 exhibits impaired ability to disrupt the formation of Smad complex and the interaction between p300 and Smads. Subsequently, SUMOylation of SNIP1 leads to the loss of SNIP1-mediated inhibition on expression of the TGF-? target genes PAI-1 and MMP2 and eventually enhances TGF-?-regulated cell migration and invasion. Twit Text FOAVip SUMO Modification Reverses Inhibitory Effects of Smad Nuclear Interacting Protein-1 in TGF- Responses ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27703003 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27703003 #FOAvip English Wikipedia <ref>{{Cite pmid|27703003 }}</ref> SUMO Modification Reverses Inhibitory Effects of Smad Nuclear Interacting Protein-1 in TGF-? Responses #MMPMID27703003 Liu S ; Long J ; Yuan B ; Zheng M ; Xiao M ; Xu J ; Lin X ; Feng XH J Biol Chem 2016[Nov]; 291 (47 ): 24418-24430 PMID27703003 show ga SNIP1 (Smad nuclear interacting protein 1) is a transcription repressor for the TGF-? and NF-?B signaling pathways through disrupting the recruitment of co-activator p300. However, it is unclear how the functions of SNIP1 in the TGF-? signaling pathway are controlled. Our present studies show that SNIP1 is covalently modified by small ubiquitin-like modifier (SUMO) in vitro and in vivo at three lysine sites: Lys(5), Lys(30), and Lys(108), with Lys(30) being the major SUMO modification site. SUMOylation of SNIP1 is enhanced by SUMO E3 ligase PIAS proteins and inhibited by SUMO proteases SENP1/2. Furthermore, we find that SUMOylation of SNIP1 attenuates its inhibitory effect in TGF-? signaling because the SUMO-conjugated form of SNIP1 exhibits impaired ability to disrupt the formation of Smad complex and the interaction between p300 and Smads. Subsequently, SUMOylation of SNIP1 leads to the loss of SNIP1-mediated inhibition on expression of the TGF-? target genes PAI-1 and MMP2 and eventually enhances TGF-?-regulated cell migration and invasion. |A549 Cells [MESH] |Animals [MESH] |COS Cells [MESH] |Cell Movement/*physiology [MESH] |Chlorocebus aethiops [MESH] |HeLa Cells [MESH] |Humans [MESH] |Intracellular Signaling Peptides and Proteins/genetics/*metabolism [MESH] |Matrix Metalloproteinase 2/biosynthesis/genetics [MESH] |Plasminogen Activator Inhibitor 1/biosynthesis/genetics [MESH] |Protein Inhibitors of Activated STAT/genetics/metabolism [MESH] |RNA-Binding Proteins [MESH] |SUMO-1 Protein/genetics/*metabolism [MESH] |Signal Transduction/*physiology [MESH] |Sumoylation/*physiology [MESH]SUMO Modification Reverses Inhibitory Effects of Smad Nuclear Interact(epmc).pdf DeepDyve Pubget Overpricing