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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Opin+Rheumatol
2016 ; 28
(6
): 571-6
Nephropedia Template TP
gab.com Text
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English Wikipedia
Aberrant immune response with consequent vascular and connective tissue
remodeling - causal to scleroderma and associated syndromes such as Raynaud
phenomenon and other fibrosing syndromes?
#MMPMID27548652
Durmus N
; Park SH
; Reibman J
; Grunig G
Curr Opin Rheumatol
2016[Nov]; 28
(6
): 571-6
PMID27548652
show ga
PURPOSE OF REVIEW: Scleroderma and other autoimmune-induced connective tissue
diseases are characterized by dysfunctions in the immune system, connective
tissue and the vasculature. We are focusing on systemic sclerosis
(SSc)-associated pulmonary hypertension, which remains a leading cause of death
with only a 50-60% of 2-year survival rate. RECENT FINDINGS: Much research and
translational efforts have been directed at understanding the immune response
that causes SSc and the networked interactions with the connective tissue and the
vasculature. One of the unexpected findings was that in some cases the pathogenic
immune response in SSc resembles the immune response to helminth parasites.
During coevolution, means of communication were developed which protect the host
from over-colonization with parasites and which protect the parasite from
excessive host responses. One explanation for the geographically clustered
occurrence of SSc is that environmental exposures combined with genetic
predisposition turn on triggers of molecular and cellular modules that were once
initiated by parasites. SUMMARY: Future research is needed to further understand
the parasite-derived signals that dampen the host response. Therapeutic helminth
infection or treatment with parasite-derived response modifiers could be
promising new management tools for autoimmune connective tissue diseases.