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10.1016/j.immuni.2016.03.007 http://scihub22266oqcxt.onion/10.1016/j.immuni.2016.03.007 C5114145!5114145 !27156386     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27156386 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunity 2016 ; 44 (5 ): 1127-39 Nephropedia Template TP {{tp|p=27156386 |t=2016. Transforming Growth Factor-? Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands |pdf=|usr=}}{{27156386 }} gab.com Text Transforming Growth Factor- Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=27156386 #FOAvip The signals guiding differentiation of innate lymphoid cells (ILCs) within tissues are not well understood. Salivary gland (SG) ILCs as well as liver and intestinal intraepithelial ILC1 have markers that denote tissue residency and transforming growth factor-? (TGF-?) imprinting. We deleted Tgfbr2 in cells expressing the ILC and NK marker NKp46 and found that SG ILCs were reduced in number. They lost distinct tissue markers, such as CD49a, and the effector molecules TRAIL and CD73. Expression of the transcription factor Eomes, which promotes NK cell differentiation, was elevated. Conversely, Eomes deletion in NKp46(+) cells enhanced TGF-?-imprinting of SG ILCs. Thus, TGF-? induces SG ILC differentiation by suppressing Eomes. TGF-? acted through a JNK-dependent, Smad4-independent pathway. Transcriptome analysis demonstrated that SG ILCs had characteristic of both NK cells and ILC1. Finally, TGF-? imprinting of SG ILCs was synchronized with SG development, highlighting the impact of tissue microenvironment on ILC development. Twit Text FOAVip Transforming Growth Factor- Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=27156386 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27156386 #FOAvip English Wikipedia <ref>{{Cite pmid|27156386 }}</ref> Transforming Growth Factor-? Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands #MMPMID27156386 Cortez VS ; Cervantes-Barragan L ; Robinette ML ; Bando JK ; Wang Y ; Geiger TL ; Gilfillan S ; Fuchs A ; Vivier E ; Sun JC ; Cella M ; Colonna M Immunity 2016[May]; 44 (5 ): 1127-39 PMID27156386 show ga The signals guiding differentiation of innate lymphoid cells (ILCs) within tissues are not well understood. Salivary gland (SG) ILCs as well as liver and intestinal intraepithelial ILC1 have markers that denote tissue residency and transforming growth factor-? (TGF-?) imprinting. We deleted Tgfbr2 in cells expressing the ILC and NK marker NKp46 and found that SG ILCs were reduced in number. They lost distinct tissue markers, such as CD49a, and the effector molecules TRAIL and CD73. Expression of the transcription factor Eomes, which promotes NK cell differentiation, was elevated. Conversely, Eomes deletion in NKp46(+) cells enhanced TGF-?-imprinting of SG ILCs. Thus, TGF-? induces SG ILC differentiation by suppressing Eomes. TGF-? acted through a JNK-dependent, Smad4-independent pathway. Transcriptome analysis demonstrated that SG ILCs had characteristic of both NK cells and ILC1. Finally, TGF-? imprinting of SG ILCs was synchronized with SG development, highlighting the impact of tissue microenvironment on ILC development. |*Cell Differentiation [MESH] |Animals [MESH] |Antigens, Ly/metabolism [MESH] |Cellular Microenvironment [MESH] |Gene Expression Profiling [MESH] |Immunity, Innate [MESH] |Killer Cells, Natural/*physiology [MESH] |Lymphocytes/*physiology [MESH] |MAP Kinase Kinase 4/metabolism [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Natural Cytotoxicity Triggering Receptor 1/metabolism [MESH] |Protein Serine-Threonine Kinases/genetics/metabolism [MESH] |Receptor, Transforming Growth Factor-beta Type II [MESH] |Receptors, Transforming Growth Factor beta/genetics/metabolism [MESH] |Salivary Glands/*immunology [MESH] |Signal Transduction [MESH] |Smad4 Protein/genetics [MESH] |T-Box Domain Proteins/genetics/metabolism [MESH]Transforming Growth Factor-? Signaling Guides the Differentiation of I(epmc).pdf DeepDyve Pubget Overpricing