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10.7554/eLife.17267 http://scihub22266oqcxt.onion/10.7554/eLife.17267 C5114016!5114016 !27855061     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27855061 &cmd=llinks): Failed to open stream: HTTP request failed! 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Rotating waves during human sleep spindles organize global patterns of activity that repeat precisely through the night |pdf=|usr=}}{{27855061 }} gab.com Text Rotating waves during human sleep spindles organize global patterns of activity that repeat precisely through the night JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=27855061 #FOAvip During sleep, the thalamus generates a characteristic pattern of transient, 11-15 Hz sleep spindle oscillations, which synchronize the cortex through large-scale thalamocortical loops. Spindles have been increasingly demonstrated to be critical for sleep-dependent consolidation of memory, but the specific neural mechanism for this process remains unclear. We show here that cortical spindles are spatiotemporally organized into circular wave-like patterns, organizing neuronal activity over tens of milliseconds, within the timescale for storing memories in large-scale networks across the cortex via spike-time dependent plasticity. These circular patterns repeat over hours of sleep with millisecond temporal precision, allowing reinforcement of the activity patterns through hundreds of reverberations. These results provide a novel mechanistic account for how global sleep oscillations and synaptic plasticity could strengthen networks distributed across the cortex to store coherent and integrated memories. Twit Text FOAVip Rotating waves during human sleep spindles organize global patterns of activity that repeat precisely through the night ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=27855061 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27855061 #FOAvip English Wikipedia <ref>{{Cite pmid|27855061 }}</ref> Rotating waves during human sleep spindles organize global patterns of activity that repeat precisely through the night #MMPMID27855061 Muller L ; Piantoni G ; Koller D ; Cash SS ; Halgren E ; Sejnowski TJ Elife 2016[Nov]; 5 (ä): ä PMID27855061 show ga During sleep, the thalamus generates a characteristic pattern of transient, 11-15 Hz sleep spindle oscillations, which synchronize the cortex through large-scale thalamocortical loops. Spindles have been increasingly demonstrated to be critical for sleep-dependent consolidation of memory, but the specific neural mechanism for this process remains unclear. We show here that cortical spindles are spatiotemporally organized into circular wave-like patterns, organizing neuronal activity over tens of milliseconds, within the timescale for storing memories in large-scale networks across the cortex via spike-time dependent plasticity. These circular patterns repeat over hours of sleep with millisecond temporal precision, allowing reinforcement of the activity patterns through hundreds of reverberations. These results provide a novel mechanistic account for how global sleep oscillations and synaptic plasticity could strengthen networks distributed across the cortex to store coherent and integrated memories. |*Brain Waves [MESH] |*Memory [MESH] |*Sleep [MESH] |Cerebral Cortex/*physiology [MESH] |Electrocorticography [MESH] |Humans [MESH] |Spatio-Temporal Analysis [MESH]Rotating waves during human sleep spindles organize global patterns of(epmc).pdf DeepDyve Pubget Overpricing