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10.1016/j.devcel.2016.09.016 http://scihub22266oqcxt.onion/10.1016/j.devcel.2016.09.016 C5113147!5113147!27746044     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27746044&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Dev+Cell 2016 ; 39 (3): 302-15 Nephropedia Template TP {{tp|p=27746044|t=2016. A balance between secreted inhibitors and edge-sensing controls gastruloid self-organization |pdf=|usr=}}{{27746044}} gab.com Text A balance between secreted inhibitors and edge-sensing controls gastruloid self-organization JO: Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=27746044 #FOAvip The earliest aspects of human embryogenesis remain mysterious. To model patterning events in the human embryo we used colonies of human embryonic stem cells (hESCs) grown on micropatterned substrate and differentiated with BMP4. These gastruloids recapitulate the embryonic arrangement of the mammalian germ layers and provide an assay to assess the structural and signaling mechanisms patterning the human gastrula. Structurally, high-density hESCs lateralize their TGF-? receptors to their lateral side in the center of the colony, while maintaining apical localization of receptors at the edge. This relocalization insulates cells at the center from apically applied ligands while maintaining response to basally presented ones. Additionally, BMP4 directly induces the expression of its own inhibitor, Noggin, generating a reaction-diffusion mechanism that underlies patterning. We develop a quantitative model that integrates edge sensing and inhibitors, to predict human fate positioning in gastruloids, and potentially the human embryo. Twit Text FOAVip A balance between secreted inhibitors and edge-sensing controls gastruloid self-organization ????Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=27746044 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27746044 #FOAvip English Wikipedia <ref>{{Cite pmid|27746044}}</ref> A balance between secreted inhibitors and edge-sensing controls gastruloid self-organization #MMPMID27746044 Etoc F; Metzger J; Ruzo A; Kirst C; Yoney A; Ozair MZ; Brivanlou AH; Siggia ED Dev Cell 2016[Nov]; 39 (3): 302-15 PMID27746044show ga The earliest aspects of human embryogenesis remain mysterious. To model patterning events in the human embryo we used colonies of human embryonic stem cells (hESCs) grown on micropatterned substrate and differentiated with BMP4. These gastruloids recapitulate the embryonic arrangement of the mammalian germ layers and provide an assay to assess the structural and signaling mechanisms patterning the human gastrula. Structurally, high-density hESCs lateralize their TGF-? receptors to their lateral side in the center of the colony, while maintaining apical localization of receptors at the edge. This relocalization insulates cells at the center from apically applied ligands while maintaining response to basally presented ones. Additionally, BMP4 directly induces the expression of its own inhibitor, Noggin, generating a reaction-diffusion mechanism that underlies patterning. We develop a quantitative model that integrates edge sensing and inhibitors, to predict human fate positioning in gastruloids, and potentially the human embryo. äA balance between secreted inhibitors and edge-sensing controls gastru(epmc).pdf DeepDyve Pubget Overpricing