Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27599471
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Emerg+Microbes+Infect
2016 ; 5
(9
): e95
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Cryptococcal meningitis in systemic lupus erythematosus patients: pooled analysis
and systematic review
#MMPMID27599471
Fang W
; Chen M
; Liu J
; Hagen F
; Ms A
; Al-Hatmi
; Zhang P
; Guo Y
; Boekhout T
; Deng D
; Xu J
; Pan W
; Liao W
Emerg Microbes Infect
2016[Sep]; 5
(9
): e95
PMID27599471
show ga
Cryptococcal meningitis is an important fungal infection among systemic lupus
erythematosus patients. We conducted a pooled analysis and systematic review to
describe the epidemiological and clinical profile of cryptococcal meningitis in
systemic lupus erythematosus patients. From two hospitals in China and nine
literature databases, cases and prevalence data were collected for pooled
analysis and meta-analysis, respectively. Categorical variables of cases were
compared using a ?(2)-test on the statistical program of SAS. A multiple
regression analysis was performed to ascertain independent predictors
significantly correlated with prognosis. Meta-analysis was conducted by the
statistical program of R. The prevalence of cryptococcal meningitis in systemic
lupus erythematosus patients was 0.5%. Patients were predominantly females and
adults. A prednisone equivalent of more than 30?mg/day before infection was
associated with higher mortality (odds ratio (OR)=9.69 (1.54, 60.73)). In all,
36.8-38.9% patients showed low lupus activity when they developed the crytococcal
infection. Moreover, 38.2% of the patients were misdiagnosed. The estimated
case-fatality rate was 23.6%. Our results suggest that more emphasis should be
placed to further understand lupus-related cryptococcal meningitis and to develop
better prophylaxis and management strategies to combat this condition.