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10.1186/s13075-016-1159-y http://scihub22266oqcxt.onion/10.1186/s13075-016-1159-y C5112700!5112700 !27852323     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27852323 &cmd=llinks): Failed to open stream: HTTP request failed! 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Circulating exosomes from patients with systemic lupus erythematosus induce an proinflammatory immune response |pdf=|usr=}}{{27852323 }} gab.com Text Circulating exosomes from patients with systemic lupus erythematosus induce an proinflammatory immune response JO: Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=27852323 #FOAvip BACKGROUND: Exosomes are involved in intercellular communication. The aim of this study was to investigate whether circulating exosomes effectively contribute to the inflammatory response in systemic lupus erythematosus (SLE). METHODS: Exosomes were purified from SLE patients and healthy controls (HCs). Healthy peripheral blood mononuclear cells (PBMCs) were stimulated with exosomes isolated from SLE patients and HCs in the presence or absence of Toll-like receptor (TLR) inhibitors. Production of interferon (IFN)-?, tumor necrosis factor (TNF)-?, interleukin (IL)-1?, and IL-6 were measured. Correlation between exosome levels and SLE disease activity was examined. RESULTS: The serum exosomes levels were significantly higher in SLE patients than in HCs. SLE exosomes induced a higher production of IFN-?, TNF-?, IL-1?, and IL-6 compared to healthy exosomes. SLE serum that was depleted of exosomes and SLE exosomes that were mechanically disrupted failed to induce any significant cytokine production. Exosome-mediated production of TNF-?, IL-1?, and IL-6 was decreased by the TLR4 antagonist, whereas that of IFN-? was suppressed by the TLR1/2, TLR7, and TLR9 antagonists. Exosome levels correlated with disease activity in SLE patients (rho?=?0.846, p?=?0.008). CONCLUSIONS: The circulating exosomes are immunologically active and their levels correlate with disease activity in SLE patients. The circulating exosomes might serve as novel biomarkers of SLE disease activity. Twit Text FOAVip Circulating exosomes from patients with systemic lupus erythematosus induce an proinflammatory immune response ????Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=27852323 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27852323 #FOAvip English Wikipedia <ref>{{Cite pmid|27852323 }}</ref> Circulating exosomes from patients with systemic lupus erythematosus induce an proinflammatory immune response #MMPMID27852323 Lee JY ; Park JK ; Lee EY ; Lee EB ; Song YW Arthritis Res Ther 2016[Nov]; 18 (1 ): 264 PMID27852323 show ga BACKGROUND: Exosomes are involved in intercellular communication. The aim of this study was to investigate whether circulating exosomes effectively contribute to the inflammatory response in systemic lupus erythematosus (SLE). METHODS: Exosomes were purified from SLE patients and healthy controls (HCs). Healthy peripheral blood mononuclear cells (PBMCs) were stimulated with exosomes isolated from SLE patients and HCs in the presence or absence of Toll-like receptor (TLR) inhibitors. Production of interferon (IFN)-?, tumor necrosis factor (TNF)-?, interleukin (IL)-1?, and IL-6 were measured. Correlation between exosome levels and SLE disease activity was examined. RESULTS: The serum exosomes levels were significantly higher in SLE patients than in HCs. SLE exosomes induced a higher production of IFN-?, TNF-?, IL-1?, and IL-6 compared to healthy exosomes. SLE serum that was depleted of exosomes and SLE exosomes that were mechanically disrupted failed to induce any significant cytokine production. Exosome-mediated production of TNF-?, IL-1?, and IL-6 was decreased by the TLR4 antagonist, whereas that of IFN-? was suppressed by the TLR1/2, TLR7, and TLR9 antagonists. Exosome levels correlated with disease activity in SLE patients (rho?=?0.846, p?=?0.008). CONCLUSIONS: The circulating exosomes are immunologically active and their levels correlate with disease activity in SLE patients. The circulating exosomes might serve as novel biomarkers of SLE disease activity. |Adult [MESH] |Cytokines/biosynthesis [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Exosomes/*immunology [MESH] |Female [MESH] |Humans [MESH] |Inflammation/*immunology [MESH] |Lupus Erythematosus, Systemic/*immunology [MESH] |Male [MESH] |Microscopy, Electron, Transmission [MESH]Circulating exosomes from patients with systemic lupus erythematosus i(epmc).pdf DeepDyve Pubget Overpricing