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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Acta+Ophthalmol
2016 ; 94
(7
): e600-e606
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Standard corneal collagen crosslinking versus transepithelial
iontophoresis-assisted corneal crosslinking, 24 months follow-up: randomized
control trial
#MMPMID27040458
Bikbova G
; Bikbov M
Acta Ophthalmol
2016[Nov]; 94
(7
): e600-e606
PMID27040458
show ga
PURPOSE: To compare the results of standard corneal crosslinking (CXL) and
transepithelial iontophoresis-assisted CXL after 24 months follow-up. MATERIAL
AND METHODS: Corneal crosslinking (CXL) was performed in a series of 149 eyes of
119 patients with keratoconus I-II of Amsler classification. Depending on the CXL
method, patients were divided into two groups: (1) 73 eyes with standard CXL and
(2) 76 eyes with transepithelial iontophoresis-assisted CXL. Depending on the
group, epithelium removal or administration of riboflavin solution by
iontophoresis for 10 min was performed, after which standard surface UVA
irradiation (370 nm, 3 mW/cm(2) ) was performed at a 5-cm distance for 30 min.
RESULTS: A statistically significant difference in corrected distance visual
acuity (CDVA) was observed between the two groups, with a better outcome in the
second group after 6 months (p = 0.037); however, no significant difference was
found 24 months after treatment (p = 0.829). Stabilization and regression of
keratometry values were achieved in both groups, but standard CXL was more
effective. The average demarcation line depth in the standard CXL group was
292 ± 14 ?m after 14 days and 172 ± 16 ?m in the transepithelial
iontophoresis-assisted CXL group. No demarcation line was detected after 1 month
and 3 months in 45% and 100% of the eyes in the second group respectively.
CONCLUSION: Transepithelial iontophoresis-assisted collagen crosslinking showed
to be less effective than standard CXL after 24 months of follow-up, possibly due
to a more superficial formation of corneal collagen crosslinks, however the
stopping of disease progression was achieved 24 months after procedure.