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10.1073/pnas.1615288113 http://scihub22266oqcxt.onion/10.1073/pnas.1615288113 C5111698!5111698!27791177     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (45): 12780-5 Nephropedia Template TP {{tp|p=27791177|t=2016. Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes |pdf=|usr=}}{{27791177}} gab.com Text Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27791177 #FOAvip Inflammatory breast cancer (IBC) is defined clinically and pathologically. Dermal lymphatic invasion is typical but is neither necessary nor sufficient for diagnosis; sentinel lymph node biopsy is contraindicated, challenging multidisciplinary management with upfront chemotherapy, surgery, and postoperative radiotherapy. Here we applied a ligand-directed ?theranostic? (a combination of therapeutic and diagnostic) enabling platform to target IBC based on adeno-associated virus/phage (AAVP)-Herpes simplex virus thymidine kinase type-1 (HSVtk) particles displaying ligands to cell surface-associated 78-kD glucose-regulated protein (GRP78). In a suite of preclinical models and human tumor samples, we show simultaneous noninvasive molecular serial PET/CT imaging and targeted suicide transgene therapy. This study shows that a tumor-specific promoter, human GRP78 (hGRP78), can drive the expression of an imaging/suicide transgene in IBC and aggressive breast cancer in vivo. Twit Text FOAVip Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27791177 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27791177 #FOAvip English Wikipedia <ref>{{Cite pmid|27791177}}</ref> Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes #MMPMID27791177 Dobroff AS; D?Angelo S; Eckhardt BL; Ferrara F; Staquicini DI; Cardó-Vila M; Staquicini FI; Nunes DN; Kim K; Driessen WHP; Hajitou A; Lomo LC; Barry M; Krishnamurthy S; Sahin A; Woodward WA; Prossnitz ER; Anderson RL; Dias-Neto E; Brown-Glaberman UA; Royce ME; Ueno NT; Cristofanilli M; Hortobagyi GN; Marchiò S; Gelovani JG; Sidman RL; Arap W; Pasqualini R Proc Natl Acad Sci U S A 2016[Nov]; 113 (45): 12780-5 PMID27791177show ga Inflammatory breast cancer (IBC) is defined clinically and pathologically. Dermal lymphatic invasion is typical but is neither necessary nor sufficient for diagnosis; sentinel lymph node biopsy is contraindicated, challenging multidisciplinary management with upfront chemotherapy, surgery, and postoperative radiotherapy. Here we applied a ligand-directed ?theranostic? (a combination of therapeutic and diagnostic) enabling platform to target IBC based on adeno-associated virus/phage (AAVP)-Herpes simplex virus thymidine kinase type-1 (HSVtk) particles displaying ligands to cell surface-associated 78-kD glucose-regulated protein (GRP78). In a suite of preclinical models and human tumor samples, we show simultaneous noninvasive molecular serial PET/CT imaging and targeted suicide transgene therapy. This study shows that a tumor-specific promoter, human GRP78 (hGRP78), can drive the expression of an imaging/suicide transgene in IBC and aggressive breast cancer in vivo. äTowards a transcriptome-based theranostic platform for unfavorable bre(epmc).pdf DeepDyve Pubget Overpricing