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10.1172/jci.insight.88632 http://scihub22266oqcxt.onion/10.1172/jci.insight.88632 C5111502!5111502 !27882348     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27882348 &cmd=llinks): Failed to open stream: HTTP request failed! 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Humanized neuronal chimeric mouse brain generated by neonatally engrafted human iPSC-derived primitive neural progenitor cells |pdf=|usr=}}{{27882348 }} gab.com Text Humanized neuronal chimeric mouse brain generated by neonatally engrafted human iPSC-derived primitive neural progenitor cells JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=27882348 #FOAvip The creation of a humanized chimeric mouse nervous system permits the study of human neural development and disease pathogenesis using human cells in vivo. Humanized glial chimeric mice with the brain and spinal cord being colonized by human glial cells have been successfully generated. However, generation of humanized chimeric mouse brains repopulated by human neurons to possess a high degree of chimerism have not been well studied. Here we created humanized neuronal chimeric mouse brains by neonatally engrafting the distinct and highly neurogenic human induced pluripotent stem cell (hiPSC)-derived rosette-type primitive neural progenitors. These neural progenitors predominantly differentiate to neurons, which disperse widely throughout the mouse brain with infiltration of the cerebral cortex and hippocampus at 6 and 13 months after transplantation. Building upon the hiPSC technology, we propose that this potentially unique humanized neuronal chimeric mouse model will provide profound opportunities to define the structure, function, and plasticity of neural networks containing human neurons derived from a broad variety of neurological disorders. Twit Text FOAVip Humanized neuronal chimeric mouse brain generated by neonatally engrafted human iPSC-derived primitive neural progenitor cells ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=27882348 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27882348 #FOAvip English Wikipedia <ref>{{Cite pmid|27882348 }}</ref> Humanized neuronal chimeric mouse brain generated by neonatally engrafted human iPSC-derived primitive neural progenitor cells #MMPMID27882348 Chen C ; Kim WY ; Jiang P JCI Insight 2016[Nov]; 1 (19 ): e88632 PMID27882348 show ga The creation of a humanized chimeric mouse nervous system permits the study of human neural development and disease pathogenesis using human cells in vivo. Humanized glial chimeric mice with the brain and spinal cord being colonized by human glial cells have been successfully generated. However, generation of humanized chimeric mouse brains repopulated by human neurons to possess a high degree of chimerism have not been well studied. Here we created humanized neuronal chimeric mouse brains by neonatally engrafting the distinct and highly neurogenic human induced pluripotent stem cell (hiPSC)-derived rosette-type primitive neural progenitors. These neural progenitors predominantly differentiate to neurons, which disperse widely throughout the mouse brain with infiltration of the cerebral cortex and hippocampus at 6 and 13 months after transplantation. Building upon the hiPSC technology, we propose that this potentially unique humanized neuronal chimeric mouse model will provide profound opportunities to define the structure, function, and plasticity of neural networks containing human neurons derived from a broad variety of neurological disorders. |*Chimera [MESH] |Animals [MESH] |Animals, Newborn [MESH] |Brain/*cytology [MESH] |Cell Differentiation [MESH] |Cells, Cultured [MESH] |Humans [MESH] |Induced Pluripotent Stem Cells/*cytology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Neural Stem Cells/*cytology [MESH] |Neuroglia/cytology [MESH] |Neurons/cytology [MESH]Humanized neuronal chimeric mouse brain generated by neonatally engraf(epmc).pdf DeepDyve Pubget Overpricing