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10.1016/j.celrep.2016.08.088 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.08.088 C5111367!5111367!27681415     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2016 ; 17 (1): 1-10 Nephropedia Template TP {{tp|p=27681415|t=2016. Dynamic regulation of a ribosome rescue pathway in erythroid cells and platelets |pdf=|usr=}}{{27681415}} gab.com Text Dynamic regulation of a ribosome rescue pathway in erythroid cells and platelets JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27681415 #FOAvip Protein synthesis continues in platelets and maturing reticulocytes, although these blood cells lack nuclei and do not make new mRNA or ribosomes. Here, we analyze translation in primary human cells from both anucleate lineages by ribosome profiling and uncover dramatic accumulation of post-termination, unrecycled ribosomes in the 3ŽUTRs of mRNAs. We demonstrate that these ribosomes accumulate as a result of the natural loss of the ribosome recycling factor ABCE1 during terminal differentiation. Induction of ribosome rescue factors PELO and HBS1L is required to support protein synthesis when ABCE1 levels fall. including for hemoglobin production during blood cell development. Our observations suggest that this distinctive loss of ABCE1 in anucleate blood lineages could sensitize them to defects in ribosome homeostasis, perhaps explaining in part why genetic defects in the fundamental process of ribosome production (?ribosomopathies?) often affect hematopoiesis specifically. Twit Text FOAVip Dynamic regulation of a ribosome rescue pathway in erythroid cells and platelets ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27681415 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27681415 #FOAvip English Wikipedia <ref>{{Cite pmid|27681415}}</ref> Dynamic regulation of a ribosome rescue pathway in erythroid cells and platelets #MMPMID27681415 Mills EW; Wangen J; Green R; Ingolia NT Cell Rep 2016[Sep]; 17 (1): 1-10 PMID27681415show ga Protein synthesis continues in platelets and maturing reticulocytes, although these blood cells lack nuclei and do not make new mRNA or ribosomes. Here, we analyze translation in primary human cells from both anucleate lineages by ribosome profiling and uncover dramatic accumulation of post-termination, unrecycled ribosomes in the 3ŽUTRs of mRNAs. We demonstrate that these ribosomes accumulate as a result of the natural loss of the ribosome recycling factor ABCE1 during terminal differentiation. Induction of ribosome rescue factors PELO and HBS1L is required to support protein synthesis when ABCE1 levels fall. including for hemoglobin production during blood cell development. Our observations suggest that this distinctive loss of ABCE1 in anucleate blood lineages could sensitize them to defects in ribosome homeostasis, perhaps explaining in part why genetic defects in the fundamental process of ribosome production (?ribosomopathies?) often affect hematopoiesis specifically. äDynamic regulation of a ribosome rescue pathway in erythroid cells and(epmc).pdf DeepDyve Pubget Overpricing