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10.1186/s12882-016-0392-6

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suck abstract from ncbi


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pmid27846800      BMC+Nephrol 2016 ; 17 (ä): ä
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  • Treatment with cinacalcet increases plasma sclerostin concentration in hemodialysis patients with secondary hyperparathyroidism #MMPMID27846800
  • Kuczera P; Adamczak M; Wi?cek A
  • BMC Nephrol 2016[]; 17 (ä): ä PMID27846800show ga
  • Background: Sclerostin is a paracrine acting factor, which is expressed in the osteocytes and articular chondrocytes. Sclerostin decreases the osteoblast-related bone formation through the inhibition of the Wnt/?-catenin pathway. Osteocytes also express the Calcium sensing receptor which is a target for cinacalcet. The aim of this study was to assess the influence of six-month cinacalcet treatment on plasma sclerostin concentration in hemodialysed patients with secondary hyperparathyroidism (sHPT). Methods: In 58 hemodialysed patients with sHPT (PTH?>?300 pg/ml) plasma sclerostin and serum PTH, calcium and phosphate concentrations were assessed before the first dose of cinacalcet and after 3 and 6 months of treatment. Results: Serum PTH concentration decreased after 3 and 6 month of treatment from 1138 (931?1345) pg/ml to 772 (551?992) pg/ml and to 635 (430?839) pg/ml, respectively. Mean serum calcium and phosphate concentrations remained stable. Plasma sclerostin concentration increased after 3 and 6 months of treatment from 1.66 (1.35?1.96) ng/ml, to 1.77 (1.43?2.12) ng/ml and to 1.87 (1.50?2.25) ng/ml, respectively. In 42 patients with cinacalcet induced serum PTH decrease plasma sclerostin concentration increased after 3 and 6 months of treatment from 1.51 (1.19?1.84) ng/ml to 1.59 (1.29?1.89) ng/ml and to 1.75 (1.42?2.01) ng/ml, respectively. Contrary, in the 16 patients without cinacalcet induced serum PTH decrease plasma sclerostin concentration was stable. Plasma sclerostin concentrations correlated inversely with serum PTH concentrations at the baseline and also after 6 months of treatment. Conclusions: 1. In hemodialysed patients with secondary hyperparathyroidism treatment with cinacalcet increases plasma sclerostin concentration 2. This effect seems to be related to decrease of serum PTH concentration.
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