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10.1038/srep37172 http://scihub22266oqcxt.onion/10.1038/srep37172 C5111104!5111104 !27849017     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27849017 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 37172 Nephropedia Template TP {{tp|p=27849017 |t=2016. ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions |pdf=|usr=}}{{27849017 }} gab.com Text ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27849017 #FOAvip Engulfment and cell motility 1 (ELMO1) functions as a guanine exchange factor for Rac1 and was recently found to protect endothelial cells from apoptosis. Genome wide association studies suggest that polymorphisms within human elmo1 act as a potential contributing factor for the development of diabetic nephropathy. Yet, the function of ELMO1 with respect to the glomerulus and how this protein contributes to renal pathology was unknown. Thus, this study aimed to identify the role played by ELMO1 in renal development in zebrafish, under hyperglycaemic conditions, and in diabetic nephropathy patients. In zebrafish, hyperglycaemia did not alter renal ELMO1 expression. However, hyperglycaemia leads to pathophysiological and functional alterations within the pronephros, which could be rescued via ELMO1 overexpression. Zebrafish ELMO1 crispants exhibited a renal pathophysiology due to increased apoptosis which could be rescued by the inhibition of apoptosis. In human samples, immunohistochemical staining of ELMO1 in nondiabetic, diabetic and polycystic kidneys localized ELMO1 in glomerular podocytes and in the tubules. However, ELMO1 was not specifically or distinctly regulated under either one of the disease conditions. Collectively, these results highlight ELMO1 as an important factor for glomerular protection and renal cell survival via decreasing apoptosis, especially under diabetic conditions. Twit Text FOAVip ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27849017 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27849017 #FOAvip English Wikipedia <ref>{{Cite pmid|27849017 }}</ref> ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions #MMPMID27849017 Sharma KR ; Heckler K ; Stoll SJ ; Hillebrands JL ; Kynast K ; Herpel E ; Porubsky S ; Elger M ; Hadaschik B ; Bieback K ; Hammes HP ; Nawroth PP ; Kroll J Sci Rep 2016[Nov]; 6 (ä): 37172 PMID27849017 show ga Engulfment and cell motility 1 (ELMO1) functions as a guanine exchange factor for Rac1 and was recently found to protect endothelial cells from apoptosis. Genome wide association studies suggest that polymorphisms within human elmo1 act as a potential contributing factor for the development of diabetic nephropathy. Yet, the function of ELMO1 with respect to the glomerulus and how this protein contributes to renal pathology was unknown. Thus, this study aimed to identify the role played by ELMO1 in renal development in zebrafish, under hyperglycaemic conditions, and in diabetic nephropathy patients. In zebrafish, hyperglycaemia did not alter renal ELMO1 expression. However, hyperglycaemia leads to pathophysiological and functional alterations within the pronephros, which could be rescued via ELMO1 overexpression. Zebrafish ELMO1 crispants exhibited a renal pathophysiology due to increased apoptosis which could be rescued by the inhibition of apoptosis. In human samples, immunohistochemical staining of ELMO1 in nondiabetic, diabetic and polycystic kidneys localized ELMO1 in glomerular podocytes and in the tubules. However, ELMO1 was not specifically or distinctly regulated under either one of the disease conditions. Collectively, these results highlight ELMO1 as an important factor for glomerular protection and renal cell survival via decreasing apoptosis, especially under diabetic conditions. |*Apoptosis [MESH] |Adaptor Proteins, Signal Transducing/genetics/*metabolism [MESH] |Animals [MESH] |Animals, Genetically Modified [MESH] |Diabetes Mellitus, Experimental/*embryology/genetics/pathology [MESH] |Humans [MESH] |Kidney/*embryology/pathology [MESH] |Zebrafish Proteins/genetics/*metabolism [MESH]ELMO1 protects renal structure and ultrafiltration in kidney developme(epmc).pdf DeepDyve Pubget Overpricing