Nucleoporin-mediated regulation of cell identity genes #MMPMID27807035
Ibarra A; Benner C; Tyagi S; Cool J; Hetzer MW
Genes Dev 2016[Oct]; 30 (20): 2253-8 PMID27807035show ga
Here, Ibarra et al. investigate the contribution of nuclear envelope components to the regulation of cell type-specific gene expression and show a role for NPC components in the regulation of cell type-specific gene expression The authors found that nucleoporin-associated superenhancers localize preferentially to the nuclear periphery, and, in the absence of nucleoporins, transcriptional changes of SE-associated genes were observed.