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10.1038/srep37252 http://scihub22266oqcxt.onion/10.1038/srep37252 C5110961!5110961 !27849031     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27849031 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 37252 Nephropedia Template TP {{tp|p=27849031 |t=2016. Neutrophil extracellular traps are indirectly triggered by lipopolysaccharide and contribute to acute lung injury |pdf=|usr=}}{{27849031 }} gab.com Text Neutrophil extracellular traps are indirectly triggered by lipopolysaccharide and contribute to acute lung injury JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27849031 #FOAvip Neutrophil extracellular traps (NETs) facilitate the extracellular killing of pathogens. However, excessive NETs formation and poor degradation are associated with exacerbated immune responses and tissue injury. In this study, we investigated the role of NETs in lipopolysaccharide (LPS)-mediated acute lung injury (ALI) and assessed the use of DNase I, for the treatment of ALI. Additionally, we focused on the controversial issue of whether LPS directly induces NETs release in vitro. NETs formation was detected in murine ALI tissue in vivo and was associated with increased NETs markers, citrullinated-histone H3 tissue levels and NET-DNA levels in BALF. Treatment with DNase I significantly degraded NETs and reduced citrullinated-histone H3 levels, which protected against ALI and ameliorated pulmonary oedema and total protein in BALF. In addition, DNase I significantly reduced IL-6 and TNF-? levels in plasma and BALF. In vitro, LPS-activated platelets rather than LPS alone efficiently induced NETs release. In conclusion, NETs formed during LPS-induced ALI, caused organ damage and initiated the inflammatory response. NETs degradation by DNase I promoted NET-protein clearance and protected against ALI in mice; thus, DNase I may be a new potential adjuvant for ALI therapy. Specifically, LPS induced NETs formation in an indirect manner via platelets activation. Twit Text FOAVip Neutrophil extracellular traps are indirectly triggered by lipopolysaccharide and contribute to acute lung injury ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27849031 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27849031 #FOAvip English Wikipedia <ref>{{Cite pmid|27849031 }}</ref> Neutrophil extracellular traps are indirectly triggered by lipopolysaccharide and contribute to acute lung injury #MMPMID27849031 Liu S ; Su X ; Pan P ; Zhang L ; Hu Y ; Tan H ; Wu D ; Liu B ; Li H ; Li H ; Li Y ; Dai M ; Li Y ; Hu C ; Tsung A Sci Rep 2016[Nov]; 6 (ä): 37252 PMID27849031 show ga Neutrophil extracellular traps (NETs) facilitate the extracellular killing of pathogens. However, excessive NETs formation and poor degradation are associated with exacerbated immune responses and tissue injury. In this study, we investigated the role of NETs in lipopolysaccharide (LPS)-mediated acute lung injury (ALI) and assessed the use of DNase I, for the treatment of ALI. Additionally, we focused on the controversial issue of whether LPS directly induces NETs release in vitro. NETs formation was detected in murine ALI tissue in vivo and was associated with increased NETs markers, citrullinated-histone H3 tissue levels and NET-DNA levels in BALF. Treatment with DNase I significantly degraded NETs and reduced citrullinated-histone H3 levels, which protected against ALI and ameliorated pulmonary oedema and total protein in BALF. In addition, DNase I significantly reduced IL-6 and TNF-? levels in plasma and BALF. In vitro, LPS-activated platelets rather than LPS alone efficiently induced NETs release. In conclusion, NETs formed during LPS-induced ALI, caused organ damage and initiated the inflammatory response. NETs degradation by DNase I promoted NET-protein clearance and protected against ALI in mice; thus, DNase I may be a new potential adjuvant for ALI therapy. Specifically, LPS induced NETs formation in an indirect manner via platelets activation. |Acute Lung Injury/chemically induced/*metabolism [MESH] |Animals [MESH] |Blood Platelets/metabolism [MESH] |Bronchoalveolar Lavage Fluid/chemistry [MESH] |Citrullination [MESH] |Deoxyribonuclease I/metabolism [MESH] |Extracellular Traps/*metabolism [MESH] |Histones/metabolism [MESH] |Interleukin-6/blood/metabolism [MESH] |Lipopolysaccharides/*pharmacology/toxicity [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Neutrophils/*drug effects/metabolism [MESH] |Pulmonary Edema/metabolism [MESH]Neutrophil extracellular traps are indirectly triggered by lipopolysac(epmc).pdf DeepDyve Pubget Overpricing