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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Clin+Biochem+Nutr
2016 ; 59
(3
): 231-237
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gab.com Text
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Determination of the adequate dosage of rebamipide, a gastric mucoprotective
drug, to prevent low-dose aspirin-induced gastrointestinal mucosal injury
#MMPMID27895392
Ota K
; Takeuchi T
; Nouda S
; Ozaki H
; Kawaguchi S
; Takahashi Y
; Harada S
; Edogawa S
; Kojima Y
; Kuramoto T
; Higuchi K
J Clin Biochem Nutr
2016[Nov]; 59
(3
): 231-237
PMID27895392
show ga
Small intestinal mucosal injury caused by low-dose aspirin is a common cause of
obscure gastrointestinal bleeding. We aimed to investigate the protective effects
and optimal dose of rebamipide for low-dose aspirin-induced gastrointestinal
mucosal injury. In this prospective randomized trial, 45 healthy volunteers (aged
20-65 years) were included and divided into three groups. The groups received
enteric-coated aspirin 100 mg (low-dose aspirin) plus omeprazole 10 mg (Group A:
proton pump inhibitor group), low-dose aspirin plus rebamipide 300 mg (Group B:
standard-dose group), or low-dose aspirin plus rebamipide 900 mg (Group C:
high-dose group). Esophagogastroduodenoscopy and video capsule endoscopy were
performed, and the fecal occult blood reaction and fecal calprotectin levels were
measured before and two weeks after drug administration. Although the fecal
calprotectin levels increased significantly in Group A, they did not increase in
Groups B and C. The esophagogastroduodenoscopic and video capsule endoscopic
findings and the fecal occult blood test findings did not differ significantly
among the three groups. In conclusion, standard-dose rebamipide is sufficient for
preventing mucosal injury of the small intestine induced by low-dose aspirin,
indicating that high-dose rebamipide is not necessary.