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Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Anesthesiol+Res+Pract 2016 ; 2016 (ä): ä Nephropedia Template TP
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Perioperative Elevation in Cell-Free DNA Levels in Patients Undergoing Cardiac Surgery: Possible Contribution of Neutrophil Extracellular Traps to Perioperative Renal Dysfunction #MMPMID27882047
Qi Y; Uchida T; Yamamoto M; Yamamoto Y; Kido K; Ito H; Ohno N; Asahara M; Yamada Y; Yamaguchi O; Mitaka C; Tomita M; Makita K
Anesthesiol Res Pract 2016[]; 2016 (ä): ä PMID27882047show ga
Background. This study aimed to determine the perioperative change in serum double-strand DNA (dsDNA) as a marker potentially reflecting neutrophil extracellular trap concentration in samples from patients undergoing cardiac surgery and to analyze a relationship between serum dsDNA concentrations and perioperative renal dysfunction. Methods. Serum dsDNA concentrations in samples that were collected during a previously conducted, prospective, multicenter, observational study were measured. Eighty patients undergoing elective cardiac surgery were studied. Serum samples were collected at baseline, immediately after surgery, and the day after surgery (POD-1). Results. Serum dsDNA concentration was significantly increased from baseline (median, 398?ng/mL [interquartile range, 372?475?ng/mL]) to immediately after surgery (median, 540?ng/mL [437?682?ng/mL], p < 0.001), and they were reduced by POD-1 (median, 323?ng/mL [256?436?ng/mL]). The difference in serum creatinine concentration between baseline and POD-1 was correlated with dsDNA concentration on POD-1 (rs = 0.61, p < 0.001). Conclusions. In patients undergoing cardiac surgery, serum dsDNA concentration is elevated postoperatively. Prolonged elevation in dsDNA concentration is correlated with perioperative renal dysfunction. Further large-scale studies are needed to determine the relationship between serum concentration of circulating dsDNA and perioperative renal dysfunction.