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2016 ; 19
(10
): 1136-1143
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Ozone therapy could attenuate tubulointerstitial injury in adenine-induced CKD
rats by mediating Nrf2 and NF-?B
#MMPMID27872711
Yu G
; Liu X
; Chen Z
; Chen H
; Wang L
; Wang Z
; Qiu T
; Weng X
Iran J Basic Med Sci
2016[Oct]; 19
(10
): 1136-1143
PMID27872711
show ga
OBJECTIVES: This study aims to determine the effects of ozone therapy on
restoring impaired Nrf2 activation to ameliorate chronic tubulointerstitial
injury in rats with adenine-induced CKD. MATERIALS AND METHODS: Sprague-Dawley
rats were fed with 0.75% adenine-containing diet to induce CKD and chronic
tubulointerstitial injury. Ozone therapy was administered by rectal insufflation.
After 4 weeks, serum and kidney samples were collected and analyzed. Renal
function and systemic electrolyte level were detected. Pathological changes in
kidney were assessed by hematoxylin-eosin staining and Masson trichrome staining.
Nrf2 activation was detected by immunohistochemistry and Western blot analyses.
The levels of SOD, CAT, GSH, PCO, and MDA were detected in the kidney.
Immunohistochemistry, Western blot, and real-time PCR analyses were performed to
evaluate the activation of the nuclear factor kappa B (NF-?B) P65 pathway and
inflammation infiltration in the tubulointerstitium of the rats. RESULTS: Ozone
therapy improved severe renal insufficiency and tubulointerstitial morphology
injury as well as restored Nrf2 activation and inhibited the NF-?B pathway in
rats with adenine-induced CKD. Ozone therapy also up-regulated anti-oxidation
enzymes (SOD, CAT, and GSH) and down-regulated oxidation products (PCO and MDA),
as well as inflammatory cytokines (IL-1?, IL-6, TNF-?, and ICAM-1) in the kidney.
CONCLUSION: These findings indicated that ozone therapy could attenuate
tubulointerstitial injury in rats with adenine-induced CKD by mediating Nrf2 and
NF-?B.
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