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10.3389/fnmol.2016.00122 http://scihub22266oqcxt.onion/10.3389/fnmol.2016.00122 C5110522!5110522 !27899882     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27899882 &cmd=llinks): Failed to open stream: HTTP request failed! 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Tumor Metabolism, the Ketogenic Diet and ?-Hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor Therapy |pdf=|usr=}}{{27899882 }} gab.com Text Tumor Metabolism, the Ketogenic Diet and -Hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor Therapy JO: Front Mol Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=27899882 #FOAvip Malignant brain tumors are devastating despite aggressive treatments such as surgical resection, chemotherapy and radiation therapy. The average life expectancy of patients with newly diagnosed glioblastoma is approximately ~18 months. It is clear that increased survival of brain tumor patients requires the design of new therapeutic modalities, especially those that enhance currently available treatments and/or limit tumor growth. One novel therapeutic arena is the metabolic dysregulation that results in an increased need for glucose in tumor cells. This phenomenon suggests that a reduction in tumor growth could be achieved by decreasing glucose availability, which can be accomplished through pharmacological means or through the use of a high-fat, low-carbohydrate ketogenic diet (KD). The KD, as the name implies, also provides increased blood ketones to support the energy needs of normal tissues. Preclinical work from a number of laboratories has shown that the KD does indeed reduce tumor growth in vivo. In addition, the KD has been shown to reduce angiogenesis, inflammation, peri-tumoral edema, migration and invasion. Furthermore, this diet can enhance the activity of radiation and chemotherapy in a mouse model of glioma, thus increasing survival. Additional studies in vitro have indicated that increasing ketones such as ?-hydroxybutyrate (?HB) in the absence of glucose reduction can also inhibit cell growth and potentiate the effects of chemotherapy and radiation. Thus, while we are only beginning to understand the pluripotent mechanisms through which the KD affects tumor growth and response to conventional therapies, the emerging data provide strong support for the use of a KD in the treatment of malignant gliomas. This has led to a limited number of clinical trials investigating the use of a KD in patients with primary and recurrent glioma. Twit Text FOAVip Tumor Metabolism, the Ketogenic Diet and -Hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor Therapy ????Front Mol Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=27899882 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27899882 #FOAvip English Wikipedia <ref>{{Cite pmid|27899882 }}</ref> Tumor Metabolism, the Ketogenic Diet and ?-Hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor Therapy #MMPMID27899882 Woolf EC ; Syed N ; Scheck AC Front Mol Neurosci 2016[]; 9 (ä): 122 PMID27899882 show ga Malignant brain tumors are devastating despite aggressive treatments such as surgical resection, chemotherapy and radiation therapy. The average life expectancy of patients with newly diagnosed glioblastoma is approximately ~18 months. It is clear that increased survival of brain tumor patients requires the design of new therapeutic modalities, especially those that enhance currently available treatments and/or limit tumor growth. One novel therapeutic arena is the metabolic dysregulation that results in an increased need for glucose in tumor cells. This phenomenon suggests that a reduction in tumor growth could be achieved by decreasing glucose availability, which can be accomplished through pharmacological means or through the use of a high-fat, low-carbohydrate ketogenic diet (KD). The KD, as the name implies, also provides increased blood ketones to support the energy needs of normal tissues. Preclinical work from a number of laboratories has shown that the KD does indeed reduce tumor growth in vivo. In addition, the KD has been shown to reduce angiogenesis, inflammation, peri-tumoral edema, migration and invasion. Furthermore, this diet can enhance the activity of radiation and chemotherapy in a mouse model of glioma, thus increasing survival. Additional studies in vitro have indicated that increasing ketones such as ?-hydroxybutyrate (?HB) in the absence of glucose reduction can also inhibit cell growth and potentiate the effects of chemotherapy and radiation. Thus, while we are only beginning to understand the pluripotent mechanisms through which the KD affects tumor growth and response to conventional therapies, the emerging data provide strong support for the use of a KD in the treatment of malignant gliomas. This has led to a limited number of clinical trials investigating the use of a KD in patients with primary and recurrent glioma. äTumor Metabolism, the Ketogenic Diet and ?-Hydroxybutyrate: Novel Appr(epmc).pdf DeepDyve Pubget Overpricing