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10.1084/jem.20160723 http://scihub22266oqcxt.onion/10.1084/jem.20160723 C5110024!5110024 !27799619     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27799619 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Exp+Med 2016 ; 213 (12 ): 2567-2574 Nephropedia Template TP {{tp|p=27799619 |t=2016. Adrenergic control of the adaptive immune response by diurnal lymphocyte recirculation through lymph nodes |pdf=|usr=}}{{27799619 }} gab.com Text Adrenergic control of the adaptive immune response by diurnal lymphocyte recirculation through lymph nodes JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27799619 #FOAvip Various aspects of the immune system display circadian rhythms. Although lymphocyte trafficking has been suggested to show diurnal variations, the mechanisms and influences on immune responses are unclear. Here, we show in mice that inputs from adrenergic nerves contribute to the diurnal variation of lymphocyte recirculation through lymph nodes (LNs), which is reflected in the magnitude of the adaptive immune response. Neural inputs to ?(2)-adrenergic receptors (?(2)ARs) expressed on lymphocytes reduced the frequency of lymphocyte egress from LNs at night, which was accompanied by an increase of lymphocyte numbers in LNs. Immunization during the period of lymphocyte accumulation in LNs enhanced antibody responses. The diurnal variation of the humoral immune response was dependent on ?(2)AR-mediated neural signals and was diminished when lymphocyte recirculation through LNs was stopped. This study reveals the physiological role of adrenergic control of lymphocyte trafficking in adaptive immunity and establishes a novel mechanism that generates diurnal rhythmicity in the immune system. Twit Text FOAVip Adrenergic control of the adaptive immune response by diurnal lymphocyte recirculation through lymph nodes ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27799619 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27799619 #FOAvip English Wikipedia <ref>{{Cite pmid|27799619 }}</ref> Adrenergic control of the adaptive immune response by diurnal lymphocyte recirculation through lymph nodes #MMPMID27799619 Suzuki K ; Hayano Y ; Nakai A ; Furuta F ; Noda M J Exp Med 2016[Nov]; 213 (12 ): 2567-2574 PMID27799619 show ga Various aspects of the immune system display circadian rhythms. Although lymphocyte trafficking has been suggested to show diurnal variations, the mechanisms and influences on immune responses are unclear. Here, we show in mice that inputs from adrenergic nerves contribute to the diurnal variation of lymphocyte recirculation through lymph nodes (LNs), which is reflected in the magnitude of the adaptive immune response. Neural inputs to ?(2)-adrenergic receptors (?(2)ARs) expressed on lymphocytes reduced the frequency of lymphocyte egress from LNs at night, which was accompanied by an increase of lymphocyte numbers in LNs. Immunization during the period of lymphocyte accumulation in LNs enhanced antibody responses. The diurnal variation of the humoral immune response was dependent on ?(2)AR-mediated neural signals and was diminished when lymphocyte recirculation through LNs was stopped. This study reveals the physiological role of adrenergic control of lymphocyte trafficking in adaptive immunity and establishes a novel mechanism that generates diurnal rhythmicity in the immune system. |Adaptive Immunity/*immunology [MESH] |Animals [MESH] |Circadian Rhythm/*immunology [MESH] |Immunity, Humoral [MESH] |Lymph Nodes/*immunology [MESH] |Lymphocyte Count [MESH] |Lymphocytes/cytology/*immunology [MESH] |Mice, Inbred C57BL [MESH]Adrenergic control of the adaptive immune response by diurnal lymphocy(epmc).pdf DeepDyve Pubget Overpricing