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10.1084/jem.20160612

http://scihub22266oqcxt.onion/10.1084/jem.20160612
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C5110022!5110022!27810927
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suck abstract from ncbi


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pmid27810927      J+Exp+Med 2016 ; 213 (12): 2759-72
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  • Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion #MMPMID27810927
  • Hu Y; Kim JH; He K; Wan Q; Kim J; Flach M; Kirchhausen T; Vortkamp A; Winau F
  • J Exp Med 2016[Nov]; 213 (12): 2759-72 PMID27810927show ga
  • The scramblase TMEM16F is indispensable for the formation of multivesicular bodies in late endosomes that facilitate TCR degradation and signal termination. Hyperactivation of TMEM16F-deficient T cells in chronic LCMV infection leads to severe T cell exhaustion and uncontrolled virus burden.
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