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10.1084/jem.20160560 http://scihub22266oqcxt.onion/10.1084/jem.20160560 C5110020!5110020 !27810925     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27810925 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Exp+Med 2016 ; 213 (12 ): 2691-2706 Nephropedia Template TP {{tp|p=27810925 |t=2016. CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP |pdf=|usr=}}{{27810925 }} gab.com Text CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27810925 #FOAvip Toll-like receptor 7 (TLR7) plays an essential role in development of systemic lupus erythematosus by co-stimulating B cells reactive to the endogenous TLR7 ligand Sm/ribonucleoprotein (RNP), a crucial lupus self-antigen. However, how the TLR7-mediated autoimmune response is regulated is not yet known. In this study, we demonstrate that CD72, an inhibitory B cell co-receptor known to prevent development of lupus, recognizes Sm/RNP at the extracellular C-type lectin-like domain (CTLD) and specifically inhibits B cell response to Sm/RNP. Moreover, the CTLD of CD72(c), a lupus-susceptible allele, binds to Sm/RNP less strongly than that of lupus-resistant CD72(a) Reduced binding of CD72(c) is supported by x-ray crystallographic analysis that reveals a considerable alteration in charge at the putative ligand-binding site. Thus, CD72 appears to specifically inhibit B cell response to the endogenous TLR7 ligand Sm/RNP through CTLD-mediated recognition of Sm/RNP, thereby preventing production of anti-Sm/RNP antibody crucial for development of lupus. Twit Text FOAVip CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27810925 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27810925 #FOAvip English Wikipedia <ref>{{Cite pmid|27810925 }}</ref> CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP #MMPMID27810925 Akatsu C ; Shinagawa K ; Numoto N ; Liu Z ; Ucar AK ; Aslam M ; Phoon S ; Adachi T ; Furukawa K ; Ito N ; Tsubata T J Exp Med 2016[Nov]; 213 (12 ): 2691-2706 PMID27810925 show ga Toll-like receptor 7 (TLR7) plays an essential role in development of systemic lupus erythematosus by co-stimulating B cells reactive to the endogenous TLR7 ligand Sm/ribonucleoprotein (RNP), a crucial lupus self-antigen. However, how the TLR7-mediated autoimmune response is regulated is not yet known. In this study, we demonstrate that CD72, an inhibitory B cell co-receptor known to prevent development of lupus, recognizes Sm/RNP at the extracellular C-type lectin-like domain (CTLD) and specifically inhibits B cell response to Sm/RNP. Moreover, the CTLD of CD72(c), a lupus-susceptible allele, binds to Sm/RNP less strongly than that of lupus-resistant CD72(a) Reduced binding of CD72(c) is supported by x-ray crystallographic analysis that reveals a considerable alteration in charge at the putative ligand-binding site. Thus, CD72 appears to specifically inhibit B cell response to the endogenous TLR7 ligand Sm/RNP through CTLD-mediated recognition of Sm/RNP, thereby preventing production of anti-Sm/RNP antibody crucial for development of lupus. |Amino Acid Sequence [MESH] |Animals [MESH] |Antibody Formation/immunology [MESH] |Antigens, CD/chemistry/*metabolism [MESH] |Antigens, Differentiation, B-Lymphocyte/chemistry/*metabolism [MESH] |B-Lymphocytes/*immunology [MESH] |Crystallography, X-Ray [MESH] |Endocytosis [MESH] |Female [MESH] |Ligands [MESH] |Lupus Erythematosus, Systemic/*immunology/pathology [MESH] |Mice, Inbred C57BL [MESH] |Models, Molecular [MESH] |Phosphorylation [MESH] |Protein Binding [MESH] |Protein Domains [MESH] |Protein Tyrosine Phosphatase, Non-Receptor Type 6/metabolism [MESH] |Ribonucleoproteins, Small Nuclear/*metabolism [MESH] |Signal Transduction [MESH] |Static Electricity [MESH] |Surface Plasmon Resonance [MESH]CD72 negatively regulates B lymphocyte responses to the lupus-related (epmc).pdf DeepDyve Pubget Overpricing