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10.1084/jem.20160206 http://scihub22266oqcxt.onion/10.1084/jem.20160206 C5110015!5110015 !27799622     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27799622 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27799622 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Exp+Med 2016 ; 213 (12 ): 2811-2829 Nephropedia Template TP {{tp|p=27799622 |t=2016. pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion |pdf=|usr=}}{{27799622 }} gab.com Text pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27799622 #FOAvip During adaptive immune responses, CD8(+) T cells with low TCR affinities are released early into the circulation before high-affinity clones become dominant at later time points. How functional avidity maturation is orchestrated in lymphoid tissue and how low-affinity cells contribute to host protection remains unclear. In this study, we used intravital imaging of reactive lymph nodes (LNs) to show that T cells rapidly attached to dendritic cells irrespective of TCR affinity, whereas one day later, the duration of these stable interactions ceased progressively with lowering peptide major histocompatibility complex (pMHC) affinity. This correlated inversely BATF (basic leucine zipper transcription factor, ATF-like) and IRF4 (interferon-regulated factor 4) induction and timing of effector differentiation, as low affinity-primed T cells acquired cytotoxic activity earlier than high affinity-primed ones. After activation, low-affinity effector CD8(+) T cells accumulated at efferent lymphatic vessels for egress, whereas high affinity-stimulated CD8(+) T cells moved to interfollicular regions in a CXCR3-dependent manner for sustained pMHC stimulation and prolonged expansion. The early release of low-affinity effector T cells led to rapid target cell elimination outside reactive LNs. Our data provide a model for affinity-dependent spatiotemporal orchestration of CD8(+) T cell activation inside LNs leading to functional avidity maturation and uncover a role for low-affinity effector T cells during early microbial containment. Twit Text FOAVip pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27799622 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27799622 #FOAvip English Wikipedia <ref>{{Cite pmid|27799622 }}</ref> pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion #MMPMID27799622 Ozga AJ ; Moalli F ; Abe J ; Swoger J ; Sharpe J ; Zehn D ; Kreutzfeldt M ; Merkler D ; Ripoll J ; Stein JV J Exp Med 2016[Nov]; 213 (12 ): 2811-2829 PMID27799622 show ga During adaptive immune responses, CD8(+) T cells with low TCR affinities are released early into the circulation before high-affinity clones become dominant at later time points. How functional avidity maturation is orchestrated in lymphoid tissue and how low-affinity cells contribute to host protection remains unclear. In this study, we used intravital imaging of reactive lymph nodes (LNs) to show that T cells rapidly attached to dendritic cells irrespective of TCR affinity, whereas one day later, the duration of these stable interactions ceased progressively with lowering peptide major histocompatibility complex (pMHC) affinity. This correlated inversely BATF (basic leucine zipper transcription factor, ATF-like) and IRF4 (interferon-regulated factor 4) induction and timing of effector differentiation, as low affinity-primed T cells acquired cytotoxic activity earlier than high affinity-primed ones. After activation, low-affinity effector CD8(+) T cells accumulated at efferent lymphatic vessels for egress, whereas high affinity-stimulated CD8(+) T cells moved to interfollicular regions in a CXCR3-dependent manner for sustained pMHC stimulation and prolonged expansion. The early release of low-affinity effector T cells led to rapid target cell elimination outside reactive LNs. Our data provide a model for affinity-dependent spatiotemporal orchestration of CD8(+) T cell activation inside LNs leading to functional avidity maturation and uncover a role for low-affinity effector T cells during early microbial containment. |Animals [MESH] |Antigens, CD/metabolism [MESH] |Antigens, Differentiation, T-Lymphocyte/metabolism [MESH] |CD8-Positive T-Lymphocytes/*cytology/*immunology [MESH] |Cell Communication/*immunology [MESH] |Cell Differentiation/*immunology [MESH] |Cell Proliferation [MESH] |Cross-Priming/immunology [MESH] |Cytotoxicity, Immunologic [MESH] |Dendritic Cells/*cytology/*immunology [MESH] |Gene Expression Regulation [MESH] |Granzymes/metabolism [MESH] |Image Processing, Computer-Assisted [MESH] |Lectins, C-Type/metabolism [MESH] |Lymph Nodes/immunology [MESH] |Lymphatic Vessels/metabolism [MESH] |Major Histocompatibility Complex/*immunology [MESH] |Mice, Inbred C57BL [MESH] |Peptides/*immunology [MESH] |Receptors, Antigen, T-Cell/metabolism [MESH] |Signal Transduction [MESH]pMHC affinity controls duration of CD8+ T cell-DC interactions and imp(epmc).pdf DeepDyve Pubget Overpricing