Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27842550
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Change in the responsiveness of interferon-stimulated genes during early
pregnancy in cows with Borna virus-1 infection
#MMPMID27842550
Takino T
; Okamura T
; Ando T
; Hagiwara K
BMC Vet Res
2016[Nov]; 12
(1
): 253
PMID27842550
show ga
BACKGROUND: Borna disease virus is a neurotropic pathogen and infects the central
nervous system. This virus infected a variety of animal species including cows.
The most of cows infected with Borna disease virus 1 (BoDV-1) exhibit subclinical
infection without any neurological symptoms throughout their lifetime. We
previously reported on the low conception rates in-seropositive cows.
Interferon-? (IFN-?) plays an important role in stable fertilization, and is
produced from the fetal side following embryo growth at 15-40 days of pregnancy.
IFN-? induces the expression of interferon-stimulated gene (ISG) 15 and Mx2 in
peripheral blood mononuclear cells (PBMCs). To understand the embryo growth and
maternal reaction during early pregnancy in cows with BoDV-1 infection, we aimed
to assess the gene expression of ISG15 and Mx2 from PBMCs in BoDV-1-seropositive
cows. RESULTS: None of the cows showed any clinical and neurological symptoms.
Among the cows that conceived, the expressions of the ISG15 and Mx2 genes were
greater in the BoDV-1-seropositive cows than in the BoDV-1-seronegative cows; the
difference was significant between the cows that conceived and those that did not
(P < 0.05). CONCLUSIONS: The expression of ISG15 and Mx2 genes during early
pregnancy significantly increased in the BoDV-1-seropositive cows and may be
important for the maintenance of stable pregnancy in BoDV-1-infected cows. In
contrast, the gene expression levels of ISG15 and Mx2 did not significantly
increase during early pregnancy in BoDV-1-seronegative cows. Thus, BoDV-1
infection may lead to instability in the maintenance of early pregnancy by
interfering with INF-? production.
free
free
free
