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suck abstract from ncbi


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pmid27746437      Intern+Med 2016 ; 55 (20): 2985-91
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  • Somatostatin-secreting Pheochromocytoma Mimicking Insulin-dependent Diabetes Mellitus #MMPMID27746437
  • Hirai H; Midorikawa S; Suzuki S; Sasano H; Watanabe T; Satoh H
  • Intern Med 2016[Oct]; 55 (20): 2985-91 PMID27746437show ga
  • We herein present the findings of a 42-year-old woman with either adrenal pheochromocytoma or intraadrenal paraganglioma that simultaneously secreted somatostatin, thus mimicking insulin-dependent diabetes mellitus. Pheochromocytoma was clinically diagnosed based on scintigraphy, elevated catecholamine levels, and finally a histopathological analysis of resected specimens. The patient had diabetic ketosis, requiring 40 U insulin for treatment. Following laparoscopic adrenalectomy, insulin therapy was discontinued and the urinary c-peptide levels changed from 5.5-9.0 to 81.3-87.0 ?g/day. Histologically, somatostatin immunoreactivity was detected and the somatostatin levels were elevated in the serum-like fluid obtained from the tumor. Clinicians should be aware of the possible occurrence of simultaneous ectopic hormone secretion in patients with pheochromocytoma.
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