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2011 ; 10
(ä): 149-154
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A comparative study pertaining to deleterious effects of diclofenac sodium and
meloxicam on kidney tissue in rats
#MMPMID27857671
Andalib S
; Naeini AM
; Garjani A
; Asl NA
; Abdollahi A
EXCLI J
2011[]; 10
(ä): 149-154
PMID27857671
show ga
NSAIDs (nonsteroidal anti-inflammatory drugs) are a class of drugs with
analgesic, anti-inflammatory, and antipyretic effects. Diclofenac sodium is one
of the world's most widely-prescribed NSAIDs. Meloxicam is another NSAID that was
approved in the last several years. Treatment with NSAIDs may result in renal
damage. Relatively, little is known about comparative nephrotoxicity of NSAIDs.
Therefore, the present study was designed to compare the adverse effects of
diclofenac sodium and meloxicam on renal tissue in rats. Forty eight Wistar male
rats were randomly assigned into 3 groups of 16 animals each. Group C served as
normal control and received normal saline. Group D and M received diclofenac
sodium (2.3 mg/kg/day) and meloxicam (2.3 mg/kg/day), respectively. After 17
days, all rats were scarified. Their kidneys were then harvested and processed
for histological examination. In addition to cellular details, renal tubular
count and diameter were assessed with the light microscope. The data were
analyzed using SPSS software. We found that the mean number of renal tubules was
significantly lower in group D, than in group C. Moreover, the mean renal tubular
diameter was significantly higher in group D than in group C. The present study
showed that a considerable degree of nephrotoxicity resulted from diclofenac
sodium, compared to meloxicam. We suggest that diclofenac sodium can be replaced
with meloxicam.
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