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10.2147/OTT.S117097 http://scihub22266oqcxt.onion/10.2147/OTT.S117097 C5108598!5108598 !27877056     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27877056 &cmd=llinks): Failed to open stream: HTTP request failed! 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A retrospective analysis of the clinicopathological and molecular characteristics of pulmonary blastoma |pdf=|usr=}}{{27877056 }} gab.com Text A retrospective analysis of the clinicopathological and molecular characteristics of pulmonary blastoma JO: Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=27877056 #FOAvip PURPOSE: The aim of this study was to analyze and summarize the clinicopathological and molecular characteristics of classic biphasic pulmonary blastoma (PB) to improve its diagnosis and treatment. PATIENTS AND METHODS: A retrospective analysis was performed in patients who were diagnosed with PB at Sun Yat-Sen University Cancer Center from March 1995 to March 2015. Genomic DNA was profiled using a capture-based targeted sequencing panel. RESULTS: Sixteen patients with an average age of 40 years were included in this study. Accurate preoperative diagnosis was very challenging as surgically resected tissues with immunohistochemical staining were required for the diagnosis. Surgery was the optimal treatment for localized disease and there was no standard management for metastatic disease. Mutations were detected among 9 out of the 56 genes profiled, including BRCA2, ERBB4, ALK, MET, BRAF, RAF1, PTEN, EGFR, and PIK3CA. CONCLUSION: Due to the low incidence rate and the reclassification of PB, no standard treatment is available. Although the numbers of cases are few with varying individual experiences, it is important to improve our understanding regarding this rare lung cancer. Targeted DNA sequencing may be of clinical use for molecular testing and the effects of targeted therapy need to be confirmed. Twit Text FOAVip A retrospective analysis of the clinicopathological and molecular characteristics of pulmonary blastoma ????Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=27877056 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27877056 #FOAvip English Wikipedia <ref>{{Cite pmid|27877056 }}</ref> A retrospective analysis of the clinicopathological and molecular characteristics of pulmonary blastoma #MMPMID27877056 Zhao YY ; Liu L ; Zhou T ; Zhou NN ; Yang YP ; Hou X ; Li Y ; Zhao HY ; Huang Y ; Zhang L Onco Targets Ther 2016[]; 9 (ä): 6915-6920 PMID27877056 show ga PURPOSE: The aim of this study was to analyze and summarize the clinicopathological and molecular characteristics of classic biphasic pulmonary blastoma (PB) to improve its diagnosis and treatment. PATIENTS AND METHODS: A retrospective analysis was performed in patients who were diagnosed with PB at Sun Yat-Sen University Cancer Center from March 1995 to March 2015. Genomic DNA was profiled using a capture-based targeted sequencing panel. RESULTS: Sixteen patients with an average age of 40 years were included in this study. Accurate preoperative diagnosis was very challenging as surgically resected tissues with immunohistochemical staining were required for the diagnosis. Surgery was the optimal treatment for localized disease and there was no standard management for metastatic disease. Mutations were detected among 9 out of the 56 genes profiled, including BRCA2, ERBB4, ALK, MET, BRAF, RAF1, PTEN, EGFR, and PIK3CA. CONCLUSION: Due to the low incidence rate and the reclassification of PB, no standard treatment is available. Although the numbers of cases are few with varying individual experiences, it is important to improve our understanding regarding this rare lung cancer. Targeted DNA sequencing may be of clinical use for molecular testing and the effects of targeted therapy need to be confirmed. äA retrospective analysis of the clinicopathological and molecular char(epmc).pdf DeepDyve Pubget Overpricing