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10.1038/nnano.2016.164 http://scihub22266oqcxt.onion/10.1038/nnano.2016.164 C5108575!5108575 !27668796     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27668796 &cmd=llinks): Failed to open stream: HTTP request failed! 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Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth |pdf=|usr=}}{{27668796 }} gab.com Text Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth JO: Nat Nanotechnol http://www.kidney.de/pget.php?&tw=1&pmid=27668796 #FOAvip The design of cancer-targeting particles with precisely tuned physicochemical properties may enhance the delivery of therapeutics and access to pharmacological targets. However, a molecular-level understanding of the interactions driving the fate of nanomedicine in biological systems remains elusive. Here, we show that ultrasmall (<10?nm in diameter) poly(ethylene glycol)-coated silica nanoparticles, functionalized with melanoma-targeting peptides, can induce a form of programmed cell death known as ferroptosis in starved cancer cells and cancer-bearing mice. Tumour xenografts in mice intravenously injected with nanoparticles using a high-dose multiple injection scheme exhibit reduced growth or regression, in a manner that is reversed by the pharmacological inhibitor of ferroptosis, liproxstatin-1. These data demonstrate that ferroptosis can be targeted by ultrasmall silica nanoparticles and may have therapeutic potential. Twit Text FOAVip Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth ????Nat Nanotechnol http://www.kidney.de/pget.php?&tw=1&pmid=27668796 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27668796 #FOAvip English Wikipedia <ref>{{Cite pmid|27668796 }}</ref> Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth #MMPMID27668796 Kim SE ; Zhang L ; Ma K ; Riegman M ; Chen F ; Ingold I ; Conrad M ; Turker MZ ; Gao M ; Jiang X ; Monette S ; Pauliah M ; Gonen M ; Zanzonico P ; Quinn T ; Wiesner U ; Bradbury MS ; Overholtzer M Nat Nanotechnol 2016[Nov]; 11 (11 ): 977-985 PMID27668796 show ga The design of cancer-targeting particles with precisely tuned physicochemical properties may enhance the delivery of therapeutics and access to pharmacological targets. However, a molecular-level understanding of the interactions driving the fate of nanomedicine in biological systems remains elusive. Here, we show that ultrasmall (<10?nm in diameter) poly(ethylene glycol)-coated silica nanoparticles, functionalized with melanoma-targeting peptides, can induce a form of programmed cell death known as ferroptosis in starved cancer cells and cancer-bearing mice. Tumour xenografts in mice intravenously injected with nanoparticles using a high-dose multiple injection scheme exhibit reduced growth or regression, in a manner that is reversed by the pharmacological inhibitor of ferroptosis, liproxstatin-1. These data demonstrate that ferroptosis can be targeted by ultrasmall silica nanoparticles and may have therapeutic potential. |Amino Acids/deficiency [MESH] |Animals [MESH] |Antineoplastic Agents/*chemistry/*pharmacology [MESH] |Cell Death/drug effects [MESH] |Cell Line, Tumor [MESH] |Humans [MESH] |Iron/*metabolism [MESH] |Lysosomes/drug effects [MESH] |Melanoma [MESH] |Mice [MESH] |Mice, SCID [MESH] |Nanoparticles/*chemistry/therapeutic use [MESH] |Particle Size [MESH] |Polyethylene Glycols/chemistry [MESH] |Quinoxalines/pharmacology [MESH] |Silicon Dioxide/chemistry [MESH] |Spiro Compounds/pharmacology [MESH] |Xenograft Model Antitumor Assays [MESH]Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cance(epmc).pdf DeepDyve Pubget Overpricing