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10.1016/j.celrep.2016.10.042 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.10.042 C5108556!5108556!27829150     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2016 ; 17 (7): 1783-94 Nephropedia Template TP {{tp|p=27829150|t=2016. Programmed death-1 culls peripheral accumulation of high affinity autoreactive CD4 T cells to protect against autoimmunity |pdf=|usr=}}{{27829150}} gab.com Text Programmed death-1 culls peripheral accumulation of high affinity autoreactive CD4 T cells to protect against autoimmunity JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27829150 #FOAvip Self-reactive CD4 T cells are incompletely deleted during thymic development, and their peripheral seeding highlights the need for additional safeguards to avert autoimmunity. Here we show an essential role for the co-inhibitory molecule programmed death-1 (PD-1) in silencing the activation of high-affinity autoreactive CD4 T cells. Each wave of self-reactive CD4 T cells that escapes thymic deletion autonomously upregulates PD-1 to maintain self-tolerance. By tracking the progeny derived from individual autoreactive CD4 T cell clones, we demonstrate that self-reactive cells with the greatest autoimmune threat and highest self-antigen affinity express the most PD-1. Reciprocally, PD-1 deprivation unleashes high-affinity self-reactive CD4 T cells in target tissues to exacerbate neuronal inflammation and autoimmune diabetes. Reliance on PD-1 to actively maintain self-tolerance may explain why exploiting this pathway by cancerous cells and invasive microbes efficiently subverts protective immunity, and why autoimmune side effects develop after PD-1 neutralizing checkpoint therapies. Twit Text FOAVip Programmed death-1 culls peripheral accumulation of high affinity autoreactive CD4 T cells to protect against autoimmunity ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27829150 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27829150 #FOAvip English Wikipedia <ref>{{Cite pmid|27829150}}</ref> Programmed death-1 culls peripheral accumulation of high affinity autoreactive CD4 T cells to protect against autoimmunity #MMPMID27829150 Jiang TT; Martinov T; Xin L; Kinder JM; Spanier JA; Fife BT; Way SS Cell Rep 2016[Nov]; 17 (7): 1783-94 PMID27829150show ga Self-reactive CD4 T cells are incompletely deleted during thymic development, and their peripheral seeding highlights the need for additional safeguards to avert autoimmunity. Here we show an essential role for the co-inhibitory molecule programmed death-1 (PD-1) in silencing the activation of high-affinity autoreactive CD4 T cells. Each wave of self-reactive CD4 T cells that escapes thymic deletion autonomously upregulates PD-1 to maintain self-tolerance. By tracking the progeny derived from individual autoreactive CD4 T cell clones, we demonstrate that self-reactive cells with the greatest autoimmune threat and highest self-antigen affinity express the most PD-1. Reciprocally, PD-1 deprivation unleashes high-affinity self-reactive CD4 T cells in target tissues to exacerbate neuronal inflammation and autoimmune diabetes. Reliance on PD-1 to actively maintain self-tolerance may explain why exploiting this pathway by cancerous cells and invasive microbes efficiently subverts protective immunity, and why autoimmune side effects develop after PD-1 neutralizing checkpoint therapies. äProgrammed death-1 culls peripheral accumulation of high affinity auto(epmc).pdf DeepDyve Pubget Overpricing