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10.1002/bies.201600051 http://scihub22266oqcxt.onion/10.1002/bies.201600051 C5108432!5108432!27545501     free     free     free       Bioessays 2016 ; 38 (10): 997-1002 Nephropedia Template TP {{tp|p=27545501|t=2016. Building on the Ccr4?Not architecture |pdf=|usr=}}{{27545501}} gab.com Text Building on the Ccr4 Not architecture JO: Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=27545501 #FOAvip In a recent issue of Nature Communications Ukleja and co?workers reported a cryo?EM 3D reconstruction of the Ccr4?Not complex from Schizosaccharomyces pombe with an immunolocalization of the different subunits. The newly gained architectural knowledge provides cues to apprehend the functional diversity of this major eukaryotic regulator. Indeed, in the cytoplasm alone, Ccr4?Not regulates translational repression, decapping and deadenylation, and the Not module additionally plays a positive role in translation. The spatial distribution of the subunits within the structure is compatible with a model proposing that the Ccr4?Not complex interacts with the 5? and 3? ends of target mRNAs, allowing different functional modules of the complex to act at different stages of the translation process, possibly within a circular constellation of the mRNA. This work opens new avenues, and reveals important gaps in our understanding regarding structure and mode of function of the Ccr4?Not complex that need to be addressed in the future. Twit Text FOAVip Building on the Ccr4 Not architecture ????Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=27545501 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27545501 #FOAvip English Wikipedia <ref>{{Cite pmid|27545501}}</ref> Building on the Ccr4?Not architecture #MMPMID27545501 Villanyi Z; Collart MA Bioessays 2016[Oct]; 38 (10): 997-1002 PMID27545501show ga In a recent issue of Nature Communications Ukleja and co?workers reported a cryo?EM 3D reconstruction of the Ccr4?Not complex from Schizosaccharomyces pombe with an immunolocalization of the different subunits. The newly gained architectural knowledge provides cues to apprehend the functional diversity of this major eukaryotic regulator. Indeed, in the cytoplasm alone, Ccr4?Not regulates translational repression, decapping and deadenylation, and the Not module additionally plays a positive role in translation. The spatial distribution of the subunits within the structure is compatible with a model proposing that the Ccr4?Not complex interacts with the 5? and 3? ends of target mRNAs, allowing different functional modules of the complex to act at different stages of the translation process, possibly within a circular constellation of the mRNA. This work opens new avenues, and reveals important gaps in our understanding regarding structure and mode of function of the Ccr4?Not complex that need to be addressed in the future. äBuilding on the Ccr4?Not architecture (epmc).pdf DeepDyve Pubget Overpricing