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10.1038/cddis.2016.206 http://scihub22266oqcxt.onion/10.1038/cddis.2016.206 C5108312!5108312 !27490927     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27490927 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2016 ; 7 (8 ): e2322 Nephropedia Template TP {{tp|p=27490927 |t=2016. TLR and NLRP3 inflammasome-dependent innate immune responses to tumor-derived autophagosomes (DRibbles) |pdf=|usr=}}{{27490927 }} gab.com Text TLR and NLRP3 inflammasome-dependent innate immune responses to tumor-derived autophagosomes (DRibbles) JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=27490927 #FOAvip Autophagosomes derived from tumor cells, also referred to as defective ribosomal products in blebs (DRibbles), have been previously shown to stimulate potent T-cell responses and mediate tumor regression when used as therapeutic cancer vaccines in multiple preclinical cancer models. In this report, we investigated the underlining mechanisms by which DRibbles induced T-cell activation, particularly how DRibbles activated antigen-presenting cells (APCs). We found that DRibbles could induce a rapid differentiation of monocytes and DC precursor (pre-DC) cells into functional APCs. DRibbles triggered innate receptor signaling via Toll-like Receptors (TLR)-2, TLR4, TLR7, TLR8, and nucleotide-binding oligomerization domain-containing protein 2 (NOD2), but not TLR3, TLR5, or TLR9. DRibbles induced PBMCs to produce pro-inflammatory cytokines, such as IL-6, IL-10, TNF-?, and IL-1?. DRibbles induced IL-1? release from PBMC or THP-1 cells without LPS priming, but required the core machinery of NLRP3 inflammasomes. Active endocytosis was required for inflammasome activation and cross presentation, and blocking endosome acidification or the ER-associated degradation (ERAD) pathway resulted in opposite effects on these two processes. Our data show that DRibbles could induce strong innate immune responses via multiple pattern recognition receptors, and explain why DRibbles could function as excellent antigen carriers to induce adaptive immune responses to both tumor cells and viruses. In contrast to the well-established inhibitory effect of autophagy on the inflammasome activation of APCs, our study demonstrates that isolated autophagosomes (DRibbles) from antigen donor cells activate inflammasomes by providing first and second signals required for IL-1? production by PMBC. Twit Text FOAVip TLR and NLRP3 inflammasome-dependent innate immune responses to tumor-derived autophagosomes (DRibbles) ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=27490927 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27490927 #FOAvip English Wikipedia <ref>{{Cite pmid|27490927 }}</ref> TLR and NLRP3 inflammasome-dependent innate immune responses to tumor-derived autophagosomes (DRibbles) #MMPMID27490927 Xing Y ; Cao R ; Hu HM Cell Death Dis 2016[Aug]; 7 (8 ): e2322 PMID27490927 show ga Autophagosomes derived from tumor cells, also referred to as defective ribosomal products in blebs (DRibbles), have been previously shown to stimulate potent T-cell responses and mediate tumor regression when used as therapeutic cancer vaccines in multiple preclinical cancer models. In this report, we investigated the underlining mechanisms by which DRibbles induced T-cell activation, particularly how DRibbles activated antigen-presenting cells (APCs). We found that DRibbles could induce a rapid differentiation of monocytes and DC precursor (pre-DC) cells into functional APCs. DRibbles triggered innate receptor signaling via Toll-like Receptors (TLR)-2, TLR4, TLR7, TLR8, and nucleotide-binding oligomerization domain-containing protein 2 (NOD2), but not TLR3, TLR5, or TLR9. DRibbles induced PBMCs to produce pro-inflammatory cytokines, such as IL-6, IL-10, TNF-?, and IL-1?. DRibbles induced IL-1? release from PBMC or THP-1 cells without LPS priming, but required the core machinery of NLRP3 inflammasomes. Active endocytosis was required for inflammasome activation and cross presentation, and blocking endosome acidification or the ER-associated degradation (ERAD) pathway resulted in opposite effects on these two processes. Our data show that DRibbles could induce strong innate immune responses via multiple pattern recognition receptors, and explain why DRibbles could function as excellent antigen carriers to induce adaptive immune responses to both tumor cells and viruses. In contrast to the well-established inhibitory effect of autophagy on the inflammasome activation of APCs, our study demonstrates that isolated autophagosomes (DRibbles) from antigen donor cells activate inflammasomes by providing first and second signals required for IL-1? production by PMBC. |*Immunity, Innate [MESH] |Autophagosomes/*metabolism [MESH] |Cell Line, Tumor [MESH] |Cytokines/metabolism [MESH] |Cytosol/metabolism [MESH] |Exosomes/metabolism [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Immunologic Memory [MESH] |Inflammasomes/*metabolism [MESH] |Inflammation Mediators/metabolism [MESH] |Interleukin-1beta/metabolism [MESH] |Leukocytes, Mononuclear/metabolism [MESH] |Lymphocyte Activation/immunology [MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism [MESH] |Neoplasms/*immunology [MESH] |Phagocytosis [MESH] |Phosphoproteins/metabolism [MESH] |Proteasome Endopeptidase Complex/metabolism [MESH] |Signal Transduction [MESH] |T-Lymphocytes/immunology [MESH] |Toll-Like Receptors/*metabolism [MESH]TLR and NLRP3 inflammasome-dependent innate immune responses to tumor-(epmc).pdf DeepDyve Pubget Overpricing